ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein Nef

Intermolecular
Cysteine 193 and cysteine 97 of AP-2 complex subunit sigma
A redox-regulated disulphide may form between cysteine 193 of Protein Nef and cysteine 97 of AP-2 complex subunit sigma.

Details

Redox score ?
81
PDB code
6owt
Structure name
structure of sivsmm nef and smm tetherin bound to the clathrin adaptor ap-2 complex
Structure deposition date
2019-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Protein Nef
Peptide B name
AP-2 complex subunit sigma
Peptide A accession
Q4JGV0
Peptide B accession
P62744
Peptide A residue number
193
Peptide B residue number
97

Ligandability

Cysteine 193 of Protein Nef

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of AP-2 complex subunit sigma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 in protein B could not be asigned to a Uniprot residue.
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