ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anoctamin-6

Intramolecular
Cysteine 352 and cysteine 356
Cysteine 349 and cysteine 807
Cysteine 338 and cysteine 365
Cysteine 596 and cysteine 601
Cysteine 447 and cysteine 450
Cysteine 251 and cysteine 262
Cysteine 331 and cysteine 372
Cysteine 450 and cysteine 456
Cysteine 331 and cysteine 338
Cysteine 331 and cysteine 365
More...
Cysteine 349 and cysteine 356
Cysteine 320 and cysteine 372
Cysteine 365 and cysteine 372
Cysteine 338 and cysteine 372
A redox-regulated disulphide may form within Anoctamin-6 between cysteines 352 and 356.

Details

Redox score ?
83
PDB code
8bc0
Structure name
cryo-em structure of ca2+-bound mtmem16f f518a q623a mutant in gdn open/closed
Structure deposition date
2022-10-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
8
% buried
7
Peptide accession
Q6P9J9
Residue number A
352
Residue number B
356
Peptide name
Anoctamin-6

Ligandability

Cysteine 352 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 349 and 807.

Details

Redox score ?
82
PDB code
8b8m
Structure name
cryo-em structure of ca2+-bound mtmem16f n562a mutant in digitonin open/closed
Structure deposition date
2022-10-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6P9J9
Residue number A
349
Residue number B
807
Peptide name
Anoctamin-6

Ligandability

Cysteine 349 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 807 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 338 and 365.

Details

Redox score ?
80
PDB code
8b8q
Structure name
structure of mtmem16f in lipid nanodiscs in the presence of ca2+
Structure deposition date
2022-10-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
14
Peptide accession
Q6P9J9
Residue number A
338
Residue number B
365
Peptide name
Anoctamin-6

Ligandability

Cysteine 338 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 596 and 601.

Details

Redox score ?
77
PDB code
8b8m
Structure name
cryo-em structure of ca2+-bound mtmem16f n562a mutant in digitonin open/closed
Structure deposition date
2022-10-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
5
% buried
92
Peptide accession
Q6P9J9
Residue number A
596
Residue number B
601
Peptide name
Anoctamin-6

Ligandability

Cysteine 596 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 601 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 447 and 450.

Details

Redox score ?
65
PDB code
6p46
Structure name
cryo-em structure of tmem16f in digitonin with calcium bound
Structure deposition date
2019-05-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
23
Minimum pKa ?
9
% buried
0
Peptide accession
Q6P9J9
Residue number A
447
Residue number B
450
Peptide name
Anoctamin-6

Ligandability

Cysteine 447 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 450 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 251 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
6qpb
Structure name
cryo-em structure of calcium-free mtmem16f lipid scramblase in digitonin
Structure deposition date
2019-02-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
60
Peptide accession
Q6P9J9
Residue number A
251
Residue number B
262
Peptide name
Anoctamin-6

Ligandability

Cysteine 251 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 331 and 372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6p49
Structure name
cryo-em structure of calcium-bound tmem16f in nanodisc with supplement of pip2 in cl2
Structure deposition date
2019-05-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
58
Peptide accession
Q6P9J9
Residue number A
331
Residue number B
372
Peptide name
Anoctamin-6

Ligandability

Cysteine 331 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 372 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 450 and 456. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6p47
Structure name
cryo-em structure of tmem16f in digitonin without calcium
Structure deposition date
2019-05-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
36
Minimum pKa ?
9
% buried
7
Peptide accession
Q6P9J9
Residue number A
450
Residue number B
456
Peptide name
Anoctamin-6

Ligandability

Cysteine 450 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 456 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 331 and 338. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
8b8k
Structure name
cryo-em structure of ca2+-bound mtmem16f n562a mutant in digitonin closed/closed
Structure deposition date
2022-10-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6P9J9
Residue number A
331
Residue number B
338
Peptide name
Anoctamin-6

Ligandability

Cysteine 331 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 338 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 331 and 365. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
8b8m
Structure name
cryo-em structure of ca2+-bound mtmem16f n562a mutant in digitonin open/closed
Structure deposition date
2022-10-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6P9J9
Residue number A
331
Residue number B
365
Peptide name
Anoctamin-6

Ligandability

Cysteine 331 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 349 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6qpb
Structure name
cryo-em structure of calcium-free mtmem16f lipid scramblase in digitonin
Structure deposition date
2019-02-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
nan
Peptide accession
Q6P9J9
Residue number A
349
Residue number B
356
Peptide name
Anoctamin-6

Ligandability

Cysteine 349 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 320 and 372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6p49
Structure name
cryo-em structure of calcium-bound tmem16f in nanodisc with supplement of pip2 in cl2
Structure deposition date
2019-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
9
% buried
62
Peptide accession
Q6P9J9
Residue number A
320
Residue number B
372
Peptide name
Anoctamin-6

Ligandability

Cysteine 320 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 372 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 365 and 372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6p47
Structure name
cryo-em structure of tmem16f in digitonin without calcium
Structure deposition date
2019-05-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
nan
Peptide accession
Q6P9J9
Residue number A
365
Residue number B
372
Peptide name
Anoctamin-6

Ligandability

Cysteine 365 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 372 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-6 between cysteines 338 and 372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
20
PDB code
6p48
Structure name
cryo-em structure of calcium-bound tmem16f in nanodisc with supplement of pip2 in cl1
Structure deposition date
2019-05-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
17
% buried
nan
Peptide accession
Q6P9J9
Residue number A
338
Residue number B
372
Peptide name
Anoctamin-6

Ligandability

Cysteine 338 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 372 of Anoctamin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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