a tool for identifying drug-targetable redox-active disulphides

Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14

Intramolecular

Cysteine 238 and cysteine 299

A redox-regulated disulphide may form within Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 between cysteines 238 and 299. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

29

PDB code

Structure name

ground state 26s proteasome (gs2)

Structure deposition date

2017-10-11

Thiol separation (Å)

10

Half-sphere exposure sum ?

76

Minimum pK_a ?

12

% buried

100

Peptide accession

Residue number A

238

Residue number B

299

Peptide name

Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14

Ligandability

Cysteine 238 of Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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