a tool for identifying drug-targetable redox-active disulphides

Interleukin-13

Intramolecular

Cysteine 64 and cysteine 90

A redox-regulated disulphide may form within Interleukin-13 between cysteines 64 and 90 (45 and 71 respectively in this structure).

Details

Redox score ?

87

PDB code

Structure name

crystal structure of the il13-il4r-il13ra ternary complex

Structure deposition date

2007-12-18

Thiol separation (Å)

2

Half-sphere exposure sum ?

44

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

64

Residue number B

90

Peptide name

Interleukin-13

Ligandability

Cysteine 64 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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