ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ighg protein

Intramolecular
Cysteine 41 and cysteine 115
Cysteine 168 and cysteine 223
A redox-regulated disulphide may form within Ighg protein between cysteines 41 and 115 (22 and 96 respectively in this structure).

Details

Redox score ?
80
PDB code
2hlf
Structure name
structure of the escherichis coli clc chloride channel y445e mutant and fab complex
Structure deposition date
2006-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q4VBH1
Residue number A
41
Residue number B
115
Peptide name
Ighg protein

Ligandability

Cysteine 41 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ighg protein between cysteines 168 and 223 (148 and 203 respectively in this structure).

Details

Redox score ?
78
PDB code
2hlf
Structure name
structure of the escherichis coli clc chloride channel y445e mutant and fab complex
Structure deposition date
2006-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q4VBH1
Residue number A
168
Residue number B
223
Peptide name
Ighg protein

Ligandability

Cysteine 168 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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