a tool for identifying drug-targetable redox-active disulphides

ATP synthase lipid-binding protein

Intermolecular

Cysteine 125 and cysteine 125

A redox-regulated disulphide may form between two units of ATP synthase lipid-binding protein at cysteines 125 and 125 (64 and 64 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

36

PDB code

Structure name

cryo-em structure of the mammalian e-state atp synthase

Structure deposition date

2019-01-11

Thiol separation (Å)

9

Half-sphere exposure sum ?

85

Minimum pK_a ?

11

% buried

100

Peptide A name

ATP synthase lipid-binding protein

Peptide B name

ATP synthase lipid-binding protein

Peptide A accession

Peptide B accession

Peptide A residue number

125

Peptide B residue number

125

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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