ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger CW-type PWWP domain protein 2

Intramolecular
Cysteine 38 and cysteine 71
Cysteine 33 and cysteine 60
Cysteine 33 and cysteine 38
Cysteine 38 and cysteine 60
Cysteine 33 and cysteine 71
Cysteine 60 and cysteine 71
A redox-regulated disulphide may form within Zinc finger CW-type PWWP domain protein 2 between cysteines 38 and 71.

Details

Redox score ?
78
PDB code
4o62
Structure name
cw-type zinc finger of zcwpw2 in complex with the amino terminus of histone h3
Structure deposition date
2013-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q504Y3
Residue number A
38
Residue number B
71
Peptide name
Zinc finger CW-type PWWP domain protein 2

Ligandability

Cysteine 38 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger CW-type PWWP domain protein 2 between cysteines 33 and 60.

Details

Redox score ?
78
PDB code
4o62
Structure name
cw-type zinc finger of zcwpw2 in complex with the amino terminus of histone h3
Structure deposition date
2013-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q504Y3
Residue number A
33
Residue number B
60
Peptide name
Zinc finger CW-type PWWP domain protein 2

Ligandability

Cysteine 33 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger CW-type PWWP domain protein 2 between cysteines 33 and 38.

Details

Redox score ?
77
PDB code
4o62
Structure name
cw-type zinc finger of zcwpw2 in complex with the amino terminus of histone h3
Structure deposition date
2013-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q504Y3
Residue number A
33
Residue number B
38
Peptide name
Zinc finger CW-type PWWP domain protein 2

Ligandability

Cysteine 33 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 38 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger CW-type PWWP domain protein 2 between cysteines 38 and 60.

Details

Redox score ?
76
PDB code
4o62
Structure name
cw-type zinc finger of zcwpw2 in complex with the amino terminus of histone h3
Structure deposition date
2013-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q504Y3
Residue number A
38
Residue number B
60
Peptide name
Zinc finger CW-type PWWP domain protein 2

Ligandability

Cysteine 38 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger CW-type PWWP domain protein 2 between cysteines 33 and 71.

Details

Redox score ?
73
PDB code
4o62
Structure name
cw-type zinc finger of zcwpw2 in complex with the amino terminus of histone h3
Structure deposition date
2013-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q504Y3
Residue number A
33
Residue number B
71
Peptide name
Zinc finger CW-type PWWP domain protein 2

Ligandability

Cysteine 33 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger CW-type PWWP domain protein 2 between cysteines 60 and 71.

Details

Redox score ?
71
PDB code
4o62
Structure name
cw-type zinc finger of zcwpw2 in complex with the amino terminus of histone h3
Structure deposition date
2013-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q504Y3
Residue number A
60
Residue number B
71
Peptide name
Zinc finger CW-type PWWP domain protein 2

Ligandability

Cysteine 60 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Zinc finger CW-type PWWP domain protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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