a tool for identifying drug-targetable redox-active disulphides

Tyrosine-protein kinase

Intramolecular

Cysteine 616 and cysteine 618

A redox-regulated disulphide may form within Tyrosine-protein kinase between cysteines 616 and 618.

Details

Redox score ?

69

PDB code

Structure name

crystal structure of jak2-v617f pseudokinase domain in complex with compound 2

Structure deposition date

2018-03-24

Thiol separation (Å)

5

Half-sphere exposure sum ?

49

Minimum pK_a ?

9

% buried

16

Peptide accession

Residue number A

616

Residue number B

618

Peptide name

Tyrosine-protein kinase

Ligandability

Cysteine 616 of Tyrosine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 618 of Tyrosine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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