ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ENSMUSG00000076577 protein

Intramolecular
Cysteine 43 and cysteine 114
Cysteine 160 and cysteine 220
A redox-regulated disulphide may form within ENSMUSG00000076577 protein between cysteines 43 and 114 (23 and 88 respectively in this structure).

Details

Redox score ?
79
PDB code
2fd6
Structure name
structure of human urokinase plasminogen activator in complex with urokinase receptor and an anti-upar antibody at 1
Structure deposition date
2005-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q52L64
Residue number A
43
Residue number B
114
Peptide name
ENSMUSG00000076577 protein

Ligandability

Cysteine 43 of ENSMUSG00000076577 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of ENSMUSG00000076577 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ENSMUSG00000076577 protein between cysteines 160 and 220 (139 and 199 respectively in this structure).

Details

Redox score ?
78
PDB code
5mp3
Structure name
crystal structure of dc8e8 fab in the complex with a 30-mer tau peptide at ph 6
Structure deposition date
2016-12-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q52L64
Residue number A
160
Residue number B
220
Peptide name
ENSMUSG00000076577 protein

Ligandability

Cysteine 160 of ENSMUSG00000076577 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of ENSMUSG00000076577 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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