ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Igk protein

Intramolecular
Cysteine 45 and cysteine 110
Cysteine 156 and cysteine 216
A redox-regulated disulphide may form within Igk protein between cysteines 45 and 110 (23 and 88 respectively in this structure).

Details

Redox score ?
79
PDB code
3oz9
Structure name
crystal structure of anti-gp41 fab nc-1
Structure deposition date
2010-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q52L95
Residue number A
45
Residue number B
110
Peptide name
Igk protein

Ligandability

Cysteine 45 of Igk protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Igk protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Igk protein between cysteines 156 and 216 (134 and 194 respectively in this structure).

Details

Redox score ?
76
PDB code
4nj9
Structure name
crystal structure of fab 8b10 in complex with mpts
Structure deposition date
2013-11-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q52L95
Residue number A
156
Residue number B
216
Peptide name
Igk protein

Ligandability

Cysteine 156 of Igk protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Igk protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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