ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RAR-related orphan receptor C isoform a variant

Intramolecular
Cysteine 320 and cysteine 393
A redox-regulated disulphide may form within RAR-related orphan receptor C isoform a variant between cysteines 320 and 393. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7jtw
Structure name
crystal structure of rorgt with compound (4r)-6-[(2,5-dichloro-3- {[(2r,4r)-1-(cyclopentanecarbonyl)-2-methylpiperidin-4- yl]oxy}phenyl)amino]-6-oxo-4-phenylhexanoic acid
Structure deposition date
2020-08-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
92
Peptide accession
Q53FZ4
Residue number A
320
Residue number B
393
Peptide name
RAR-related orphan receptor C isoform a variant

Ligandability

Cysteine 320 of RAR-related orphan receptor C isoform a variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of RAR-related orphan receptor C isoform a variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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