TAP binding protein-like variant

Intramolecular

A redox-regulated disulphide may form within TAP binding protein-like variant between cysteines 321 and 382 (300 and 361 respectively in this structure).

Details

Redox score ?

PDB code

7rno

Structure name

model of the ac-6-fp/hpmr1/bb2m/tapbpr complex from integrated docking, nmr and restrained md

Structure deposition date

2021-07-29

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q53GH5

Residue number A

321

Residue number B

382

Peptide name

TAP binding protein-like variant

Ligandability

Cysteine 321 of TAP binding protein-like variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of TAP binding protein-like variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TAP binding protein-like variant between cysteines 212 and 283 (191 and 262 respectively in this structure).

Details

Redox score ?

PDB code

7rno

Structure name

model of the ac-6-fp/hpmr1/bb2m/tapbpr complex from integrated docking, nmr and restrained md

Structure deposition date

2021-07-29

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Q53GH5

Residue number A

212

Residue number B

283

Peptide name

TAP binding protein-like variant

Ligandability

Cysteine 212 of TAP binding protein-like variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of TAP binding protein-like variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TAP binding protein-like variant between cysteines 39 and 122 (18 and 101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?