a tool for identifying drug-targetable redox-active disulphides

Protein mono-ADP-ribosyltransferase PARP10

Intramolecular

Cysteine 981 and cysteine 983 L

A redox-regulated disulphide may form within Protein mono-ADP-ribosyltransferase PARP10 between cysteines 981 and 983.

Details

Redox score ?

71

PDB code

Structure name

human poly(adp-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide

Structure deposition date

2009-05-26

Thiol separation (Å)

5

Half-sphere exposure sum ?

28

Minimum pK_a ?

9

% buried

0

Peptide accession

Residue number A

981

Residue number B

983

Peptide name

Protein mono-ADP-ribosyltransferase PARP10

Ligandability

Cysteine 981 of Protein mono-ADP-ribosyltransferase PARP10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 983 of Protein mono-ADP-ribosyltransferase PARP10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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