ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Acylglycerol kinase, mitochondrial

Intermolecular
Cysteine 43 and cysteine 149 of Mitochondrial import inner membrane translocase subunit Tim29
Intramolecular
Cysteine 334 and cysteine 365
A redox-regulated disulphide may form between cysteine 43 of Acylglycerol kinase, mitochondrial and cysteine 149 of Mitochondrial import inner membrane translocase subunit Tim29.

Details

Redox score ?
77
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
66
Peptide A name
Acylglycerol kinase, mitochondrial
Peptide B name
Mitochondrial import inner membrane translocase subunit Tim29
Peptide A accession
Q53H12
Peptide B accession
Q9BSF4
Peptide A residue number
43
Peptide B residue number
149

Ligandability

Cysteine 43 of Acylglycerol kinase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Mitochondrial import inner membrane translocase subunit Tim29

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acylglycerol kinase, mitochondrial between cysteines 334 and 365.

Details

Redox score ?
72
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
25
Peptide accession
Q53H12
Residue number A
334
Residue number B
365
Peptide name
Acylglycerol kinase, mitochondrial

Ligandability

Cysteine 334 of Acylglycerol kinase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Acylglycerol kinase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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