a tool for identifying drug-targetable redox-active disulphides

Cordon-bleu protein-like 1

Intramolecular

Cysteine 177 and cysteine 180

A redox-regulated disulphide may form within Cordon-bleu protein-like 1 between cysteines 177 and 180 (41 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

51

PDB code

Structure name

solution structure of the novel identified ubiquitin-like domain in the human cobl-like 1 protein

Structure deposition date

2005-12-14

Thiol separation (Å)

8

Half-sphere exposure sum ?

60

Minimum pK_a ?

10

% buried

28

Peptide accession

Residue number A

177

Residue number B

180

Peptide name

Cordon-bleu protein-like 1

Ligandability

Cysteine 177 of Cordon-bleu protein-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Cordon-bleu protein-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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