ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Low molecular weight phosphotyrosine protein phosphatase

Intramolecular
Cysteine 146 and cysteine 150
Cysteine 146 and cysteine 149
Cysteine 149 and cysteine 150
Cysteine 13 and cysteine 18
Cysteine 13 and cysteine 146
Cysteine 63 and cysteine 146
Cysteine 13 and cysteine 91
A redox-regulated disulphide may form within Low molecular weight phosphotyrosine protein phosphatase between cysteines 146 and 150. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2p4u
Structure name
crystal structure of acid phosphatase 1 (acp1) from mus musculus
Structure deposition date
2007-03-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
100
Peptide accession
Q561M1
Residue number A
146
Residue number B
150
Peptide name
Low molecular weight phosphotyrosine protein phosphatase

Ligandability

Cysteine 146 of Low molecular weight phosphotyrosine protein phosphatase

Cysteine 150 of Low molecular weight phosphotyrosine protein phosphatase

A redox-regulated disulphide may form within Low molecular weight phosphotyrosine protein phosphatase between cysteines 146 and 149. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2p4u
Structure name
crystal structure of acid phosphatase 1 (acp1) from mus musculus
Structure deposition date
2007-03-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
83
Peptide accession
Q561M1
Residue number A
146
Residue number B
149
Peptide name
Low molecular weight phosphotyrosine protein phosphatase

Ligandability

Cysteine 146 of Low molecular weight phosphotyrosine protein phosphatase

Cysteine 149 of Low molecular weight phosphotyrosine protein phosphatase

A redox-regulated disulphide may form within Low molecular weight phosphotyrosine protein phosphatase between cysteines 149 and 150. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2p4u
Structure name
crystal structure of acid phosphatase 1 (acp1) from mus musculus
Structure deposition date
2007-03-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
86
Peptide accession
Q561M1
Residue number A
149
Residue number B
150
Peptide name
Low molecular weight phosphotyrosine protein phosphatase

Ligandability

Cysteine 149 of Low molecular weight phosphotyrosine protein phosphatase

Cysteine 150 of Low molecular weight phosphotyrosine protein phosphatase

A redox-regulated disulphide may form within Low molecular weight phosphotyrosine protein phosphatase between cysteines 13 and 18. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2p4u
Structure name
crystal structure of acid phosphatase 1 (acp1) from mus musculus
Structure deposition date
2007-03-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
97
Minimum pKa ?
9
% buried
86
Peptide accession
Q561M1
Residue number A
13
Residue number B
18
Peptide name
Low molecular weight phosphotyrosine protein phosphatase

Ligandability

Cysteine 13 of Low molecular weight phosphotyrosine protein phosphatase

Cysteine 18 of Low molecular weight phosphotyrosine protein phosphatase

A redox-regulated disulphide may form within Low molecular weight phosphotyrosine protein phosphatase between cysteines 13 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2p4u
Structure name
crystal structure of acid phosphatase 1 (acp1) from mus musculus
Structure deposition date
2007-03-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
9
% buried
100
Peptide accession
Q561M1
Residue number A
13
Residue number B
146
Peptide name
Low molecular weight phosphotyrosine protein phosphatase

Ligandability

Cysteine 13 of Low molecular weight phosphotyrosine protein phosphatase

Cysteine 146 of Low molecular weight phosphotyrosine protein phosphatase

A redox-regulated disulphide may form within Low molecular weight phosphotyrosine protein phosphatase between cysteines 63 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
2p4u
Structure name
crystal structure of acid phosphatase 1 (acp1) from mus musculus
Structure deposition date
2007-03-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
74
Peptide accession
Q561M1
Residue number A
63
Residue number B
146
Peptide name
Low molecular weight phosphotyrosine protein phosphatase

Ligandability

Cysteine 63 of Low molecular weight phosphotyrosine protein phosphatase

Cysteine 146 of Low molecular weight phosphotyrosine protein phosphatase

A redox-regulated disulphide may form within Low molecular weight phosphotyrosine protein phosphatase between cysteines 13 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
2p4u
Structure name
crystal structure of acid phosphatase 1 (acp1) from mus musculus
Structure deposition date
2007-03-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
96
Minimum pKa ?
9
% buried
91
Peptide accession
Q561M1
Residue number A
13
Residue number B
91
Peptide name
Low molecular weight phosphotyrosine protein phosphatase

Ligandability

Cysteine 13 of Low molecular weight phosphotyrosine protein phosphatase

Cysteine 91 of Low molecular weight phosphotyrosine protein phosphatase

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