ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ighg protein

Intramolecular
Cysteine 41 and cysteine 117
Cysteine 169 and cysteine 224
A redox-regulated disulphide may form within Ighg protein between cysteines 41 and 117 (22 and 96 respectively in this structure).

Details

Redox score ?
81
PDB code
2hfe
Structure name
rb+ complex of a k channel with an amide to ester substitution in the selectivity filter
Structure deposition date
2006-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q569B4
Residue number A
41
Residue number B
117
Peptide name
Ighg protein

Ligandability

Cysteine 41 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ighg protein between cysteines 169 and 224 (145 and 200 respectively in this structure).

Details

Redox score ?
78
PDB code
2hfe
Structure name
rb+ complex of a k channel with an amide to ester substitution in the selectivity filter
Structure deposition date
2006-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q569B4
Residue number A
169
Residue number B
224
Peptide name
Ighg protein

Ligandability

Cysteine 169 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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