ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class I antigen

Intramolecular
Cysteine 110 and cysteine 173
Cysteine 212 and cysteine 268
A redox-regulated disulphide may form within MHC class I antigen between cysteines 110 and 173 (101 and 164 respectively in this structure).

Details

Redox score ?
82
PDB code
3bvn
Structure name
high resolution crystal structure of hla-b*1402 in complex with the latent membrane protein 2 peptide (lmp2) of epstein-barr virus
Structure deposition date
2008-01-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q56H30
Residue number A
110
Residue number B
173
Peptide name
MHC class I antigen

Ligandability

Cysteine 110 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I antigen between cysteines 212 and 268 (203 and 259 respectively in this structure).

Details

Redox score ?
79
PDB code
3bvn
Structure name
high resolution crystal structure of hla-b*1402 in complex with the latent membrane protein 2 peptide (lmp2) of epstein-barr virus
Structure deposition date
2008-01-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q56H30
Residue number A
212
Residue number B
268
Peptide name
MHC class I antigen

Ligandability

Cysteine 212 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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