ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein sidekick-2

Intramolecular
Cysteine 52 and cysteine 95
Cysteine 241 and cysteine 288
Cysteine 334 and cysteine 384
A redox-regulated disulphide may form within Protein sidekick-2 between cysteines 52 and 95 (28 and 71 respectively in this structure).

Details

Redox score ?
82
PDB code
5k70
Structure name
sidekick-2 immunoglobulin domains 1-4 h18r/n22s mutant
Structure deposition date
2016-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6V4S5
Residue number A
52
Residue number B
95
Peptide name
Protein sidekick-2

Ligandability

Cysteine 52 of Protein sidekick-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Protein sidekick-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein sidekick-2 between cysteines 241 and 288 (217 and 264 respectively in this structure).

Details

Redox score ?
80
PDB code
5k70
Structure name
sidekick-2 immunoglobulin domains 1-4 h18r/n22s mutant
Structure deposition date
2016-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6V4S5
Residue number A
241
Residue number B
288
Peptide name
Protein sidekick-2

Ligandability

Cysteine 241 of Protein sidekick-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 288 of Protein sidekick-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein sidekick-2 between cysteines 334 and 384 (310 and 360 respectively in this structure).

Details

Redox score ?
80
PDB code
5k6x
Structure name
sidekick-2 immunoglobulin domains 1-4, crystal form 1
Structure deposition date
2016-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6V4S5
Residue number A
334
Residue number B
384
Peptide name
Protein sidekick-2

Ligandability

Cysteine 334 of Protein sidekick-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 384 of Protein sidekick-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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