a tool for identifying drug-targetable redox-active disulphides

Major prion protein

Intramolecular

Cysteine 186 and cysteine 221

A redox-regulated disulphide may form within Major prion protein between cysteines 186 and 221 (179 and 214 respectively in this structure).

Details

Redox score ?

82

PDB code

Structure name

tammar wallaby prion protein (121-230)

Structure deposition date

2009-02-24

Thiol separation (Å)

2

Half-sphere exposure sum ?

86

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

186

Residue number B

221

Peptide name

Major prion protein

Ligandability

Cysteine 186 of Major prion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Major prion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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