ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA class I histocompatibility antigen, E alpha chain variant

Intramolecular
Cysteine 119 and cysteine 182
Cysteine 221 and cysteine 277
A redox-regulated disulphide may form within HLA class I histocompatibility antigen, E alpha chain variant between cysteines 119 and 182 (101 and 164 respectively in this structure).

Details

Redox score ?
82
PDB code
6ghn
Structure name
hla-e*01:03 in complex with the mtb44 peptide variant: mtb44*p9-phe
Structure deposition date
2018-05-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59EE1
Residue number A
119
Residue number B
182
Peptide name
HLA class I histocompatibility antigen, E alpha chain variant

Ligandability

Cysteine 119 of HLA class I histocompatibility antigen, E alpha chain variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of HLA class I histocompatibility antigen, E alpha chain variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class I histocompatibility antigen, E alpha chain variant between cysteines 221 and 277 (203 and 259 respectively in this structure).

Details

Redox score ?
81
PDB code
6ghn
Structure name
hla-e*01:03 in complex with the mtb44 peptide variant: mtb44*p9-phe
Structure deposition date
2018-05-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59EE1
Residue number A
221
Residue number B
277
Peptide name
HLA class I histocompatibility antigen, E alpha chain variant

Ligandability

Cysteine 221 of HLA class I histocompatibility antigen, E alpha chain variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of HLA class I histocompatibility antigen, E alpha chain variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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