Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Intramolecular
Cysteine 90 and cysteine 111
Cysteine 65 and cysteine 115
Cysteine 74 and cysteine 98
Cysteine 111 and cysteine 115
Cysteine 90 and cysteine 115
Cysteine 65 and cysteine 111
Cysteine 65 and cysteine 90
4bqd B 51 B 72
A redox-regulated disulphide may form within Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant between cysteines 90 and 111 (51 and 72 respectively in this structure).
Details
Redox score ?
86
PDB code
4bqd
Structure name
kd1 of human tfpi in complex with a synthetic peptide
Structure deposition date
2013-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59EE5
Residue number A
90
Residue number B
111
Peptide name
Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Ligandability
Cysteine 90 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Cysteine 111 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
4bqd B 26 B 76
A redox-regulated disulphide may form within Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant between cysteines 65 and 115 (26 and 76 respectively in this structure).
Details
Redox score ?
86
PDB code
4bqd
Structure name
kd1 of human tfpi in complex with a synthetic peptide
Structure deposition date
2013-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59EE5
Residue number A
65
Residue number B
115
Peptide name
Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Ligandability
Cysteine 65 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Cysteine 115 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
4bqd B 35 B 59
A redox-regulated disulphide may form within Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant between cysteines 74 and 98 (35 and 59 respectively in this structure).
Details
Redox score ?
84
PDB code
4bqd
Structure name
kd1 of human tfpi in complex with a synthetic peptide
Structure deposition date
2013-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59EE5
Residue number A
74
Residue number B
98
Peptide name
Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Ligandability
Cysteine 74 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Cysteine 98 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
4bqd A 72 A 76
A redox-regulated disulphide may form within Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant between cysteines 111 and 115 (72 and 76 respectively in this structure).
Details
Redox score ?
69
PDB code
4bqd
Structure name
kd1 of human tfpi in complex with a synthetic peptide
Structure deposition date
2013-05-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59EE5
Residue number A
111
Residue number B
115
Peptide name
Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Ligandability
Cysteine 111 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Cysteine 115 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
4bqd A 51 A 76
A redox-regulated disulphide may form within Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant between cysteines 90 and 115 (51 and 76 respectively in this structure).
Details
Redox score ?
63
PDB code
4bqd
Structure name
kd1 of human tfpi in complex with a synthetic peptide
Structure deposition date
2013-05-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59EE5
Residue number A
90
Residue number B
115
Peptide name
Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Ligandability
Cysteine 90 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Cysteine 115 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
4bqd A 26 A 72
A redox-regulated disulphide may form within Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant between cysteines 65 and 111 (26 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
4bqd
Structure name
kd1 of human tfpi in complex with a synthetic peptide
Structure deposition date
2013-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59EE5
Residue number A
65
Residue number B
111
Peptide name
Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Ligandability
Cysteine 65 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Cysteine 111 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
4bqd B 26 B 51
A redox-regulated disulphide may form within Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant between cysteines 65 and 90 (26 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4bqd
Structure name
kd1 of human tfpi in complex with a synthetic peptide
Structure deposition date
2013-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59EE5
Residue number A
65
Residue number B
90
Peptide name
Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Ligandability
Cysteine 65 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
Cysteine 90 of Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
If this tool was useful for finding a disulphide, please cite: