a tool for identifying drug-targetable redox-active disulphides

Thyroid hormone receptor, alpha isoform 1 variant

Intramolecular

Cysteine 241 and cysteine 242

A redox-regulated disulphide may form within Thyroid hormone receptor, alpha isoform 1 variant between cysteines 241 and 242 (254 and 255 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

44

PDB code

Structure name

structure of tr-alfa bound to selective thyromimetic gc-1 in p212121 space group

Structure deposition date

2009-08-07

Thiol separation (Å)

7

Half-sphere exposure sum ?

85

Minimum pK_a ?

13

% buried

100

Peptide accession

Residue number A

241

Residue number B

242

Peptide name

Thyroid hormone receptor, alpha isoform 1 variant

Ligandability

Cysteine 241 of Thyroid hormone receptor, alpha isoform 1 variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 242 of Thyroid hormone receptor, alpha isoform 1 variant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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