Tripartite motif-containing 25 variant
Intermolecular
Cysteine 365 and cysteine 365
Intramolecular
Cysteine 27 and cysteine 30
Cysteine 27 and cysteine 50
Cysteine 30 and cysteine 47
Cysteine 42 and cysteine 67
Cysteine 64 and cysteine 67
Cysteine 27 and cysteine 47
Cysteine 47 and cysteine 50
Cysteine 42 and cysteine 64
Cysteine 30 and cysteine 50
Cysteine 47 and cysteine 84
4ltb A 351 B 351
A redox-regulated disulphide may form between two units of Tripartite motif-containing 25 variant at cysteines 365 and 365 (351 and 351 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
4ltb
Structure name
coiled-coil domain of trim25
Structure deposition date
2013-07-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
34
Peptide A name
Tripartite motif-containing 25 variant
Peptide B name
Tripartite motif-containing 25 variant
Peptide A accession
Q59GW5
Peptide B accession
Q59GW5
Peptide A residue number
365
Peptide B residue number
365
Ligandability
5eya G 13 G 16
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 27 and 30 (13 and 16 respectively in this structure).
Details
Redox score ?
81
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
73
Minimum pKa ?
5
% buried
nan
Peptide accession
Q59GW5
Residue number A
27
Residue number B
30
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 27 of Tripartite motif-containing 25 variant
Cysteine 30 of Tripartite motif-containing 25 variant
5eya G 13 G 36
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 27 and 50 (13 and 36 respectively in this structure).
Details
Redox score ?
81
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
5
% buried
77
Peptide accession
Q59GW5
Residue number A
27
Residue number B
50
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 27 of Tripartite motif-containing 25 variant
Cysteine 50 of Tripartite motif-containing 25 variant
5eya F 16 F 33
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 30 and 47 (16 and 33 respectively in this structure).
Details
Redox score ?
81
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
69
Minimum pKa ?
5
% buried
61
Peptide accession
Q59GW5
Residue number A
30
Residue number B
47
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 30 of Tripartite motif-containing 25 variant
Cysteine 47 of Tripartite motif-containing 25 variant
5eya F 28 F 53
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 42 and 67 (28 and 53 respectively in this structure).
Details
Redox score ?
77
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
6
% buried
nan
Peptide accession
Q59GW5
Residue number A
42
Residue number B
67
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 42 of Tripartite motif-containing 25 variant
Cysteine 67 of Tripartite motif-containing 25 variant
5eya G 50 G 53
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 64 and 67 (50 and 53 respectively in this structure).
Details
Redox score ?
76
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
6
% buried
94
Peptide accession
Q59GW5
Residue number A
64
Residue number B
67
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 64 of Tripartite motif-containing 25 variant
Cysteine 67 of Tripartite motif-containing 25 variant
5eya F 13 F 33
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 27 and 47 (13 and 33 respectively in this structure).
Details
Redox score ?
65
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
14
% buried
nan
Peptide accession
Q59GW5
Residue number A
27
Residue number B
47
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 27 of Tripartite motif-containing 25 variant
Cysteine 47 of Tripartite motif-containing 25 variant
5eya F 33 F 36
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 47 and 50 (33 and 36 respectively in this structure).
Details
Redox score ?
63
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
14
% buried
62
Peptide accession
Q59GW5
Residue number A
47
Residue number B
50
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 47 of Tripartite motif-containing 25 variant
Cysteine 50 of Tripartite motif-containing 25 variant
5eya F 28 F 50
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 42 and 64 (28 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
19
% buried
nan
Peptide accession
Q59GW5
Residue number A
42
Residue number B
64
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 42 of Tripartite motif-containing 25 variant
Cysteine 64 of Tripartite motif-containing 25 variant
5eya G 16 G 36
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 30 and 50 (16 and 36 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
22
% buried
nan
Peptide accession
Q59GW5
Residue number A
30
Residue number B
50
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 30 of Tripartite motif-containing 25 variant
Cysteine 50 of Tripartite motif-containing 25 variant
5eya F 33 F 70
A redox-regulated disulphide may form within Tripartite motif-containing 25 variant between cysteines 47 and 84 (33 and 70 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
5eya
Structure name
trim25 ring domain in complex with ubc13-ub conjugate
Structure deposition date
2015-11-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
66
Peptide accession
Q59GW5
Residue number A
47
Residue number B
84
Peptide name
Tripartite motif-containing 25 variant
Ligandability
Cysteine 47 of Tripartite motif-containing 25 variant
Cysteine 84 of Tripartite motif-containing 25 variant
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