receptor protein-tyrosine kinase
Intramolecular
Cysteine 348 and cysteine 356
Cysteine 364 and cysteine 373
Cysteine 288 and cysteine 297
Cysteine 335 and cysteine 344
Cysteine 260 and cysteine 273
Cysteine 350 and cysteine 362
Cysteine 301 and cysteine 307
Cysteine 244 and cysteine 253
Cysteine 257 and cysteine 266
Cysteine 322 and cysteine 331
More...Cysteine 275 and cysteine 284
Cysteine 313 and cysteine 320
Cysteine 77 and cysteine 135
Cysteine 403 and cysteine 457
Cysteine 348 and cysteine 350
Cysteine 348 and cysteine 362
Cysteine 350 and cysteine 356
Cysteine 260 and cysteine 266
Cysteine 362 and cysteine 373
Cysteine 350 and cysteine 373
Cysteine 273 and cysteine 284
Cysteine 257 and cysteine 260
Cysteine 266 and cysteine 273
Cysteine 260 and cysteine 284
Cysteine 356 and cysteine 362
Cysteine 362 and cysteine 364
Cysteine 257 and cysteine 273
Cysteine 350 and cysteine 364
Cysteine 273 and cysteine 275
Cysteine 260 and cysteine 275
Cysteine 322 and cysteine 335
Cysteine 244 and cysteine 257
Cysteine 344 and cysteine 356
Cysteine 253 and cysteine 257
Cysteine 348 and cysteine 373
Cysteine 331 and cysteine 335
Cysteine 307 and cysteine 331
Cysteine 275 and cysteine 297
Cysteine 344 and cysteine 348
Cysteine 335 and cysteine 356
4k0v A 315 A 323
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 348 and 356 (315 and 323 respectively in this structure).
Details
Redox score ?
88
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
348
Residue number B
356
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 348 of receptor protein-tyrosine kinase
Cysteine 356 of receptor protein-tyrosine kinase
4k0v A 331 A 340
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 364 and 373 (331 and 340 respectively in this structure).
Details
Redox score ?
88
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
364
Residue number B
373
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 364 of receptor protein-tyrosine kinase
Cysteine 373 of receptor protein-tyrosine kinase
4k0v A 255 A 264
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 288 and 297 (255 and 264 respectively in this structure).
Details
Redox score ?
88
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
288
Residue number B
297
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 288 of receptor protein-tyrosine kinase
Cysteine 297 of receptor protein-tyrosine kinase
4k0v A 302 A 311
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 335 and 344 (302 and 311 respectively in this structure).
Details
Redox score ?
87
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
335
Residue number B
344
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 335 of receptor protein-tyrosine kinase
Cysteine 344 of receptor protein-tyrosine kinase
4k0v A 227 A 240
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 260 and 273 (227 and 240 respectively in this structure).
Details
Redox score ?
86
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
260
Residue number B
273
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 260 of receptor protein-tyrosine kinase
Cysteine 273 of receptor protein-tyrosine kinase
4k0v A 317 A 329
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 350 and 362 (317 and 329 respectively in this structure).
Details
Redox score ?
86
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
350
Residue number B
362
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 350 of receptor protein-tyrosine kinase
Cysteine 362 of receptor protein-tyrosine kinase
4k0v A 268 A 274
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 301 and 307 (268 and 274 respectively in this structure).
Details
Redox score ?
86
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
301
Residue number B
307
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 301 of receptor protein-tyrosine kinase
Cysteine 307 of receptor protein-tyrosine kinase
4k0v A 211 A 220
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 244 and 253 (211 and 220 respectively in this structure).
Details
Redox score ?
86
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
244
Residue number B
253
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 244 of receptor protein-tyrosine kinase
Cysteine 253 of receptor protein-tyrosine kinase
4k0v A 224 A 233
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 257 and 266 (224 and 233 respectively in this structure).
Details
Redox score ?
84
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
257
Residue number B
266
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 257 of receptor protein-tyrosine kinase
Cysteine 266 of receptor protein-tyrosine kinase
4k0v A 289 A 298
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 322 and 331 (289 and 298 respectively in this structure).
Details
Redox score ?
83
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
322
Residue number B
331
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 322 of receptor protein-tyrosine kinase
Cysteine 331 of receptor protein-tyrosine kinase
4k0v A 242 A 251
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 275 and 284 (242 and 251 respectively in this structure).
Details
Redox score ?
81
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
275
Residue number B
284
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 275 of receptor protein-tyrosine kinase
Cysteine 284 of receptor protein-tyrosine kinase
4k0v A 280 A 287
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 313 and 320 (280 and 287 respectively in this structure).
Details
Redox score ?
80
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
313
Residue number B
320
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 313 of receptor protein-tyrosine kinase
Cysteine 320 of receptor protein-tyrosine kinase
4k0v A 44 A 102
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 77 and 135 (44 and 102 respectively in this structure).
Details
Redox score ?
80
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
77
Residue number B
135
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 77 of receptor protein-tyrosine kinase
Cysteine 135 of receptor protein-tyrosine kinase
4k0v A 370 A 424
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 403 and 457 (370 and 424 respectively in this structure).
Details
Redox score ?
79
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
403
Residue number B
457
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 403 of receptor protein-tyrosine kinase
Cysteine 457 of receptor protein-tyrosine kinase
4k0v A 315 A 317
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 348 and 350 (315 and 317 respectively in this structure).
Details
Redox score ?
77
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
348
Residue number B
350
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 348 of receptor protein-tyrosine kinase
Cysteine 350 of receptor protein-tyrosine kinase
4k0v A 315 A 329
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 348 and 362 (315 and 329 respectively in this structure).
Details
Redox score ?
73
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
348
Residue number B
362
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 348 of receptor protein-tyrosine kinase
Cysteine 362 of receptor protein-tyrosine kinase
4k0v A 317 A 323
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 350 and 356 (317 and 323 respectively in this structure).
Details
Redox score ?
69
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
350
Residue number B
356
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 350 of receptor protein-tyrosine kinase
Cysteine 356 of receptor protein-tyrosine kinase
4k0v A 227 A 233
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 260 and 266 (227 and 233 respectively in this structure).
Details
Redox score ?
69
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
260
Residue number B
266
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 260 of receptor protein-tyrosine kinase
Cysteine 266 of receptor protein-tyrosine kinase
4k0v A 329 A 340
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 362 and 373 (329 and 340 respectively in this structure).
Details
Redox score ?
69
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
362
Residue number B
373
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 362 of receptor protein-tyrosine kinase
Cysteine 373 of receptor protein-tyrosine kinase
4k0v A 317 A 340
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 350 and 373 (317 and 340 respectively in this structure).
Details
Redox score ?
68
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
350
Residue number B
373
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 350 of receptor protein-tyrosine kinase
Cysteine 373 of receptor protein-tyrosine kinase
4k0v A 240 A 251
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 273 and 284 (240 and 251 respectively in this structure).
Details
Redox score ?
68
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
273
Residue number B
284
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 273 of receptor protein-tyrosine kinase
Cysteine 284 of receptor protein-tyrosine kinase
4k0v A 224 A 227
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 257 and 260 (224 and 227 respectively in this structure).
Details
Redox score ?
67
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
257
Residue number B
260
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 257 of receptor protein-tyrosine kinase
Cysteine 260 of receptor protein-tyrosine kinase
4k0v A 233 A 240
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 266 and 273 (233 and 240 respectively in this structure).
Details
Redox score ?
66
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
266
Residue number B
273
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 266 of receptor protein-tyrosine kinase
Cysteine 273 of receptor protein-tyrosine kinase
4k0v A 227 A 251
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 260 and 284 (227 and 251 respectively in this structure).
Details
Redox score ?
66
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
260
Residue number B
284
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 260 of receptor protein-tyrosine kinase
Cysteine 284 of receptor protein-tyrosine kinase
4k0v A 323 A 329
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 356 and 362 (323 and 329 respectively in this structure).
Details
Redox score ?
64
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
356
Residue number B
362
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 356 of receptor protein-tyrosine kinase
Cysteine 362 of receptor protein-tyrosine kinase
4k0v A 329 A 331
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 362 and 364 (329 and 331 respectively in this structure).
Details
Redox score ?
63
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
362
Residue number B
364
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 362 of receptor protein-tyrosine kinase
Cysteine 364 of receptor protein-tyrosine kinase
4k0v A 224 A 240
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 257 and 273 (224 and 240 respectively in this structure).
Details
Redox score ?
61
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
257
Residue number B
273
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 257 of receptor protein-tyrosine kinase
Cysteine 273 of receptor protein-tyrosine kinase
4k0v A 317 A 331
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 350 and 364 (317 and 331 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
350
Residue number B
364
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 350 of receptor protein-tyrosine kinase
Cysteine 364 of receptor protein-tyrosine kinase
4k0v A 240 A 242
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 273 and 275 (240 and 242 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
273
Residue number B
275
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 273 of receptor protein-tyrosine kinase
Cysteine 275 of receptor protein-tyrosine kinase
4k0v A 227 A 242
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 260 and 275 (227 and 242 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
260
Residue number B
275
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 260 of receptor protein-tyrosine kinase
Cysteine 275 of receptor protein-tyrosine kinase
4k0v A 289 A 302
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 322 and 335 (289 and 302 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
322
Residue number B
335
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 322 of receptor protein-tyrosine kinase
Cysteine 335 of receptor protein-tyrosine kinase
4k0v A 211 A 224
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 244 and 257 (211 and 224 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
244
Residue number B
257
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 244 of receptor protein-tyrosine kinase
Cysteine 257 of receptor protein-tyrosine kinase
4k0v A 311 A 323
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 344 and 356 (311 and 323 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
344
Residue number B
356
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 344 of receptor protein-tyrosine kinase
Cysteine 356 of receptor protein-tyrosine kinase
4k0v A 220 A 224
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 253 and 257 (220 and 224 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
253
Residue number B
257
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 253 of receptor protein-tyrosine kinase
Cysteine 257 of receptor protein-tyrosine kinase
4k0v A 315 A 340
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 348 and 373 (315 and 340 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
348
Residue number B
373
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 348 of receptor protein-tyrosine kinase
Cysteine 373 of receptor protein-tyrosine kinase
4k0v A 298 A 302
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 331 and 335 (298 and 302 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
331
Residue number B
335
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 331 of receptor protein-tyrosine kinase
Cysteine 335 of receptor protein-tyrosine kinase
4k0v A 274 A 298
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 307 and 331 (274 and 298 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
307
Residue number B
331
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 307 of receptor protein-tyrosine kinase
Cysteine 331 of receptor protein-tyrosine kinase
4k0v A 242 A 264
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 275 and 297 (242 and 264 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
275
Residue number B
297
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 275 of receptor protein-tyrosine kinase
Cysteine 297 of receptor protein-tyrosine kinase
4k0v A 311 A 315
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 344 and 348 (311 and 315 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
344
Residue number B
348
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 344 of receptor protein-tyrosine kinase
Cysteine 348 of receptor protein-tyrosine kinase
4k0v A 302 A 323
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 335 and 356 (302 and 323 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4k0v
Structure name
structural basis for angiopoietin-1 mediated signaling initiation
Structure deposition date
2013-04-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59HG2
Residue number A
335
Residue number B
356
Peptide name
receptor protein-tyrosine kinase
Ligandability
Cysteine 335 of receptor protein-tyrosine kinase
Cysteine 356 of receptor protein-tyrosine kinase
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