ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anti-RhD monoclonal T125 gamma1 heavy chain

Intramolecular
Cysteine 172 and cysteine 228
Cysteine 41 and cysteine 115
A redox-regulated disulphide may form within Anti-RhD monoclonal T125 gamma1 heavy chain between cysteines 172 and 228 (153 and 209 respectively in this structure).

Details

Redox score ?
79
PDB code
6umx
Structure name
structural basis for specific inhibition of extracellular activation of pro/latent myostatin by srk-015
Structure deposition date
2019-10-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5EFE5
Residue number A
172
Residue number B
228
Peptide name
Anti-RhD monoclonal T125 gamma1 heavy chain

Ligandability

Cysteine 172 of Anti-RhD monoclonal T125 gamma1 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Anti-RhD monoclonal T125 gamma1 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anti-RhD monoclonal T125 gamma1 heavy chain between cysteines 41 and 115 (22 and 96 respectively in this structure).

Details

Redox score ?
79
PDB code
6umx
Structure name
structural basis for specific inhibition of extracellular activation of pro/latent myostatin by srk-015
Structure deposition date
2019-10-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5EFE5
Residue number A
41
Residue number B
115
Peptide name
Anti-RhD monoclonal T125 gamma1 heavy chain

Ligandability

Cysteine 41 of Anti-RhD monoclonal T125 gamma1 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Anti-RhD monoclonal T125 gamma1 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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