ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA class II histocompatibility antigen DP beta chain

Intramolecular
Cysteine 144 and cysteine 200
Cysteine 44 and cysteine 106
A redox-regulated disulphide may form within HLA class II histocompatibility antigen DP beta chain between cysteines 144 and 200 (115 and 171 respectively in this structure).

Details

Redox score ?
80
PDB code
4p5k
Structure name
structural basis of chronic beryllium disease: bridging the gap between allergy and autoimmunity
Structure deposition date
2014-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5EP54
Residue number A
144
Residue number B
200
Peptide name
HLA class II histocompatibility antigen DP beta chain

Ligandability

Cysteine 144 of HLA class II histocompatibility antigen DP beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of HLA class II histocompatibility antigen DP beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class II histocompatibility antigen DP beta chain between cysteines 44 and 106 (15 and 77 respectively in this structure).

Details

Redox score ?
79
PDB code
4p5k
Structure name
structural basis of chronic beryllium disease: bridging the gap between allergy and autoimmunity
Structure deposition date
2014-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5EP54
Residue number A
44
Residue number B
106
Peptide name
HLA class II histocompatibility antigen DP beta chain

Ligandability

Cysteine 44 of HLA class II histocompatibility antigen DP beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of HLA class II histocompatibility antigen DP beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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