ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Transient receptor potential cation channel, subfamily M, member 3

Intramolecular
Cysteine 1067 and cysteine 1084
Cysteine 672 and cysteine 675
A redox-regulated disulphide may form within Transient receptor potential cation channel, subfamily M, member 3 between cysteines 1067 and 1084.

Details

Redox score ?
71
PDB code
8ed9
Structure name
cryo-em structure of trpm3 ion channel in the presence with pip2 and pregs, state 2
Structure deposition date
2022-09-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q5F4S7
Residue number A
1067
Residue number B
1084
Peptide name
Transient receptor potential cation channel, subfamily M, member 3

Ligandability

Cysteine 1067 of Transient receptor potential cation channel, subfamily M, member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1084 of Transient receptor potential cation channel, subfamily M, member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel, subfamily M, member 3 between cysteines 672 and 675. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
8ddx
Structure name
cryo-em structure of trpm3 ion channel in complex with gbg in the presence of pip2, tethered by alfa-nanobody
Structure deposition date
2022-06-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
10
% buried
84
Peptide accession
Q5F4S7
Residue number A
672
Residue number B
675
Peptide name
Transient receptor potential cation channel, subfamily M, member 3

Ligandability

Cysteine 672 of Transient receptor potential cation channel, subfamily M, member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 675 of Transient receptor potential cation channel, subfamily M, member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: