ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IGL@ protein

Intramolecular
Cysteine 41 and cysteine 106
Cysteine 154 and cysteine 213
A redox-regulated disulphide may form within IGL@ protein between cysteines 41 and 106 (23 and 88 respectively in this structure).

Details

Redox score ?
79
PDB code
2fl5
Structure name
cofactor-containing antibodies: crystal structure of the original yellow antibody
Structure deposition date
2006-01-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5FWF9
Residue number A
41
Residue number B
106
Peptide name
IGL@ protein

Ligandability

Cysteine 41 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGL@ protein between cysteines 154 and 213 (134 and 194 respectively in this structure).

Details

Redox score ?
78
PDB code
2fl5
Structure name
cofactor-containing antibodies: crystal structure of the original yellow antibody
Structure deposition date
2006-01-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5FWF9
Residue number A
154
Residue number B
213
Peptide name
IGL@ protein

Ligandability

Cysteine 154 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 213 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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