a tool for identifying drug-targetable redox-active disulphides

BCL-6 corepressor-like protein 1

Intramolecular

Cysteine 1682 and cysteine 1694

A redox-regulated disulphide may form within BCL-6 corepressor-like protein 1 between cysteines 1682 and 1694 (1608 and 1620 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

pcgf1 ub fold (rawul)/bcorl1 pufd complex

Structure deposition date

2012-10-24

Thiol separation (Å)

9

Half-sphere exposure sum ?

63

Minimum pK_a ?

10

% buried

69

Peptide accession

Residue number A

1682

Residue number B

1694

Peptide name

BCL-6 corepressor-like protein 1

Ligandability

Cysteine 1682 of BCL-6 corepressor-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1694 of BCL-6 corepressor-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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