ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein

Intramolecular
Cysteine 39 and cysteine 41
A redox-regulated disulphide may form within Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein between cysteines 39 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7x1n
Structure name
crystal structure of mef2d-mre complex
Structure deposition date
2022-02-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
81
Peptide accession
Q5IRN4
Residue number A
39
Residue number B
41
Peptide name
Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein

Ligandability

Cysteine 39 of Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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