ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytochrome c oxidase assembly factor 6 homolog

Intermolecular
Cysteine 59 and cysteine 58
Intramolecular
Cysteine 68 and cysteine 79
Cysteine 58 and cysteine 90 L
Cysteine 59 and cysteine 90 L
A redox-regulated disulphide may form between two units of Cytochrome c oxidase assembly factor 6 homolog at cysteines 59 and 58. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6pcf
Structure name
human coa6: w59c mutant protein
Structure deposition date
2019-06-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Cytochrome c oxidase assembly factor 6 homolog
Peptide B name
Cytochrome c oxidase assembly factor 6 homolog
Peptide A accession
Q5JTJ3
Peptide B accession
Q5JTJ3
Peptide A residue number
59
Peptide B residue number
58

Ligandability

Cysteine 59 of Cytochrome c oxidase assembly factor 6 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Cytochrome c oxidase assembly factor 6 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 6 homolog between cysteines 68 and 79.

Details

Redox score ?
87
PDB code
6pce
Structure name
human coa6
Structure deposition date
2019-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5JTJ3
Residue number A
68
Residue number B
79
Peptide name
Cytochrome c oxidase assembly factor 6 homolog

Ligandability

Cysteine 68 of Cytochrome c oxidase assembly factor 6 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Cytochrome c oxidase assembly factor 6 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 6 homolog between cysteines 58 and 90.

Details

Redox score ?
85
PDB code
6pcf
Structure name
human coa6: w59c mutant protein
Structure deposition date
2019-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5JTJ3
Residue number A
58
Residue number B
90
Peptide name
Cytochrome c oxidase assembly factor 6 homolog

Ligandability

Cysteine 58 of Cytochrome c oxidase assembly factor 6 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of Cytochrome c oxidase assembly factor 6 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 6 homolog between cysteines 59 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6pcf
Structure name
human coa6: w59c mutant protein
Structure deposition date
2019-06-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5JTJ3
Residue number A
59
Residue number B
90
Peptide name
Cytochrome c oxidase assembly factor 6 homolog

Ligandability

Cysteine 59 of Cytochrome c oxidase assembly factor 6 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of Cytochrome c oxidase assembly factor 6 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 in protein A could not be asigned to a Uniprot residue.
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