ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IQ motif and SEC7 domain-containing protein 2

Intramolecular
Cysteine 974 and cysteine 976
Cysteine 974 and cysteine 975
Cysteine 865 and cysteine 867
Cysteine 975 and cysteine 976
A redox-regulated disulphide may form within IQ motif and SEC7 domain-containing protein 2 between cysteines 974 and 976 (623 and 625 respectively in this structure).

Details

Redox score ?
60
PDB code
6fae
Structure name
the sec7 domain of iqsec2 (brag1) in complex with the small gtpase arf1
Structure deposition date
2017-12-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
46
Peptide accession
Q5JU85
Residue number A
974
Residue number B
976
Peptide name
IQ motif and SEC7 domain-containing protein 2

Ligandability

Cysteine 974 of IQ motif and SEC7 domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 976 of IQ motif and SEC7 domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IQ motif and SEC7 domain-containing protein 2 between cysteines 974 and 975 (623 and 624 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
6fae
Structure name
the sec7 domain of iqsec2 (brag1) in complex with the small gtpase arf1
Structure deposition date
2017-12-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
44
Peptide accession
Q5JU85
Residue number A
974
Residue number B
975
Peptide name
IQ motif and SEC7 domain-containing protein 2

Ligandability

Cysteine 974 of IQ motif and SEC7 domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 975 of IQ motif and SEC7 domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IQ motif and SEC7 domain-containing protein 2 between cysteines 865 and 867 (514 and 516 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6fae
Structure name
the sec7 domain of iqsec2 (brag1) in complex with the small gtpase arf1
Structure deposition date
2017-12-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
34
Peptide accession
Q5JU85
Residue number A
865
Residue number B
867
Peptide name
IQ motif and SEC7 domain-containing protein 2

Ligandability

Cysteine 865 of IQ motif and SEC7 domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 867 of IQ motif and SEC7 domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IQ motif and SEC7 domain-containing protein 2 between cysteines 975 and 976 (624 and 625 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6fae
Structure name
the sec7 domain of iqsec2 (brag1) in complex with the small gtpase arf1
Structure deposition date
2017-12-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
48
Peptide accession
Q5JU85
Residue number A
975
Residue number B
976
Peptide name
IQ motif and SEC7 domain-containing protein 2

Ligandability

Cysteine 975 of IQ motif and SEC7 domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 976 of IQ motif and SEC7 domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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