ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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WD repeat domain phosphoinositide-interacting protein 3

Intramolecular
Cysteine 297 and cysteine 312
Cysteine 246 and cysteine 299
Cysteine 235 and cysteine 299
Cysteine 297 and cysteine 299
Cysteine 235 and cysteine 246
Cysteine 190 and cysteine 235
Cysteine 299 and cysteine 312
Cysteine 235 and cysteine 297
Cysteine 246 and cysteine 297
Cysteine 190 and cysteine 299
A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 297 and 312 (270 and 285 respectively in this structure).

Details

Redox score ?
79
PDB code
6klr
Structure name
crystal structure of human wipi3 in complex with the wir-peptide from atg2a
Structure deposition date
2019-07-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
7
% buried
62
Peptide accession
Q5MNZ6
Residue number A
297
Residue number B
312
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 297 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 246 and 299 (237 and 272 respectively in this structure).

Details

Redox score ?
64
PDB code
6klr
Structure name
crystal structure of human wipi3 in complex with the wir-peptide from atg2a
Structure deposition date
2019-07-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
92
Minimum pKa ?
10
% buried
100
Peptide accession
Q5MNZ6
Residue number A
246
Residue number B
299
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 246 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 235 and 299 (226 and 272 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6klr
Structure name
crystal structure of human wipi3 in complex with the wir-peptide from atg2a
Structure deposition date
2019-07-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
14
% buried
100
Peptide accession
Q5MNZ6
Residue number A
235
Residue number B
299
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 235 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 297 and 299 (270 and 272 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6klr
Structure name
crystal structure of human wipi3 in complex with the wir-peptide from atg2a
Structure deposition date
2019-07-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
14
% buried
88
Peptide accession
Q5MNZ6
Residue number A
297
Residue number B
299
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 297 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 235 and 246 (226 and 237 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6klr
Structure name
crystal structure of human wipi3 in complex with the wir-peptide from atg2a
Structure deposition date
2019-07-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
10
% buried
100
Peptide accession
Q5MNZ6
Residue number A
235
Residue number B
246
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 235 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 246 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 190 and 235 (181 and 226 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6iyy
Structure name
crystal structure of human wipi3,loop deletion mutant
Structure deposition date
2018-12-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
Q5MNZ6
Residue number A
190
Residue number B
235
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 190 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 235 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 299 and 312 (272 and 285 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6klr
Structure name
crystal structure of human wipi3 in complex with the wir-peptide from atg2a
Structure deposition date
2019-07-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
7
% buried
75
Peptide accession
Q5MNZ6
Residue number A
299
Residue number B
312
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 299 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 235 and 297 (226 and 270 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6klr
Structure name
crystal structure of human wipi3 in complex with the wir-peptide from atg2a
Structure deposition date
2019-07-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
17
% buried
88
Peptide accession
Q5MNZ6
Residue number A
235
Residue number B
297
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 235 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 246 and 297 (237 and 270 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6iyy
Structure name
crystal structure of human wipi3,loop deletion mutant
Structure deposition date
2018-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
10
% buried
93
Peptide accession
Q5MNZ6
Residue number A
246
Residue number B
297
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 246 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat domain phosphoinositide-interacting protein 3 between cysteines 190 and 299 (181 and 272 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6iyy
Structure name
crystal structure of human wipi3,loop deletion mutant
Structure deposition date
2018-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
94
Minimum pKa ?
13
% buried
100
Peptide accession
Q5MNZ6
Residue number A
190
Residue number B
299
Peptide name
WD repeat domain phosphoinositide-interacting protein 3

Ligandability

Cysteine 190 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of WD repeat domain phosphoinositide-interacting protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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