ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Urokinase plasminogen activator

Intramolecular
Cysteine 293 and cysteine 362
Cysteine 197 and cysteine 268
Cysteine 325 and cysteine 341
Cysteine 352 and cysteine 380
Cysteine 189 and cysteine 205
A redox-regulated disulphide may form within Urokinase plasminogen activator between cysteines 293 and 362 (136 and 201 respectively in this structure).

Details

Redox score ?
83
PDB code
2o8w
Structure name
crystal structure and binding epitopes of urokinase-type plasminogen activator (c122a/n145q/s195a) in complex with inhibitors
Structure deposition date
2006-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5PY49
Residue number A
293
Residue number B
362
Peptide name
Urokinase plasminogen activator

Ligandability

Cysteine 293 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 362 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase plasminogen activator between cysteines 197 and 268 (50 and 111 respectively in this structure).

Details

Redox score ?
83
PDB code
2o8u
Structure name
crystal structure and binding epitopes of urokinase-type plasminogen activator (c122a/n145q/s195a) in complex with inhibitors
Structure deposition date
2006-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5PY49
Residue number A
197
Residue number B
268
Peptide name
Urokinase plasminogen activator

Ligandability

Cysteine 197 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase plasminogen activator between cysteines 325 and 341 (168 and 182 respectively in this structure).

Details

Redox score ?
81
PDB code
2o8t
Structure name
crystal structure and binding epitopes of urokinase-type plasminogen activator (c122a/n145q) in complex with inhibitors
Structure deposition date
2006-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5PY49
Residue number A
325
Residue number B
341
Peptide name
Urokinase plasminogen activator

Ligandability

Cysteine 325 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 341 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase plasminogen activator between cysteines 352 and 380 (191 and 220 respectively in this structure).

Details

Redox score ?
80
PDB code
2o8w
Structure name
crystal structure and binding epitopes of urokinase-type plasminogen activator (c122a/n145q/s195a) in complex with inhibitors
Structure deposition date
2006-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5PY49
Residue number A
352
Residue number B
380
Peptide name
Urokinase plasminogen activator

Ligandability

Cysteine 352 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase plasminogen activator between cysteines 189 and 205 (42 and 58 respectively in this structure).

Details

Redox score ?
79
PDB code
2o8u
Structure name
crystal structure and binding epitopes of urokinase-type plasminogen activator (c122a/n145q/s195a) in complex with inhibitors
Structure deposition date
2006-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5PY49
Residue number A
189
Residue number B
205
Peptide name
Urokinase plasminogen activator

Ligandability

Cysteine 189 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Urokinase plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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