ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rab GTPase-activating protein 1-like

Intramolecular
Cysteine 554 and cysteine 641
Cysteine 722 and cysteine 777
A redox-regulated disulphide may form within Rab GTPase-activating protein 1-like between cysteines 554 and 641.

Details

Redox score ?
64
PDB code
3hzj
Structure name
crystal structure of the rabgap domain of the rabgap1l protein
Structure deposition date
2009-06-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5R372
Residue number A
554
Residue number B
641
Peptide name
Rab GTPase-activating protein 1-like

Ligandability

Cysteine 554 of Rab GTPase-activating protein 1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 641 of Rab GTPase-activating protein 1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab GTPase-activating protein 1-like between cysteines 722 and 777. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3hzj
Structure name
crystal structure of the rabgap domain of the rabgap1l protein
Structure deposition date
2009-06-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5R372
Residue number A
722
Residue number B
777
Peptide name
Rab GTPase-activating protein 1-like

Ligandability

Cysteine 722 of Rab GTPase-activating protein 1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 777 of Rab GTPase-activating protein 1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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