ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Calcium homeostasis modulator protein 6

Intermolecular
Cysteine 82 and cysteine 198
Cysteine 81 and cysteine 198
A redox-regulated disulphide may form between two units of Calcium homeostasis modulator protein 6 at cysteines 82 and 198.

Details

Redox score ?
84
PDB code
6ytv
Structure name
cryo-em structure of decameric human calhm6 in the presence of ca2+
Structure deposition date
2020-04-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
Calcium homeostasis modulator protein 6
Peptide B name
Calcium homeostasis modulator protein 6
Peptide A accession
Q5R3K3
Peptide B accession
Q5R3K3
Peptide A residue number
82
Peptide B residue number
198

Ligandability

Cysteine 82 of Calcium homeostasis modulator protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Calcium homeostasis modulator protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Calcium homeostasis modulator protein 6 at cysteines 81 and 198.

Details

Redox score ?
66
PDB code
6ytv
Structure name
cryo-em structure of decameric human calhm6 in the presence of ca2+
Structure deposition date
2020-04-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
0
Peptide A name
Calcium homeostasis modulator protein 6
Peptide B name
Calcium homeostasis modulator protein 6
Peptide A accession
Q5R3K3
Peptide B accession
Q5R3K3
Peptide A residue number
81
Peptide B residue number
198

Ligandability

Cysteine 81 of Calcium homeostasis modulator protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Calcium homeostasis modulator protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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