Ubiquitin-40S ribosomal protein S27a
Intramolecular
Cysteine 121 and cysteine 126
Cysteine 121 and cysteine 144
Cysteine 126 and cysteine 144
Cysteine 141 and cysteine 144
Cysteine 121 and cysteine 141
Cysteine 126 and cysteine 141
Cysteine 144 and cysteine 145
Cysteine 141 and cysteine 145
Cysteine 121 and cysteine 145
Cysteine 126 and cysteine 145
6g5h f 121 f 126
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 121 and 126.
Details
Redox score ?
86
PDB code
6g5h
Structure name
cryo-em structure of a late human pre-40s ribosomal subunit - mature
Structure deposition date
2018-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
20
Peptide accession
Q5RKT7
Residue number A
121
Residue number B
126
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 121 of Ubiquitin-40S ribosomal protein S27a
Cysteine 126 of Ubiquitin-40S ribosomal protein S27a
6g5i f 121 f 144
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 121 and 144.
Details
Redox score ?
86
PDB code
6g5i
Structure name
cryo-em structure of a late human pre-40s ribosomal subunit - state r
Structure deposition date
2018-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
27
Peptide accession
Q5RKT7
Residue number A
121
Residue number B
144
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 121 of Ubiquitin-40S ribosomal protein S27a
Cysteine 144 of Ubiquitin-40S ribosomal protein S27a
5a2q f 126 f 144
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 126 and 144.
Details
Redox score ?
85
PDB code
5a2q
Structure name
structure of the hcv ires bound to the human ribosome
Structure deposition date
2015-05-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
7
% buried
28
Peptide accession
Q5RKT7
Residue number A
126
Residue number B
144
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 126 of Ubiquitin-40S ribosomal protein S27a
Cysteine 144 of Ubiquitin-40S ribosomal protein S27a
5oa3 f 141 f 144
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 141 and 144.
Details
Redox score ?
84
PDB code
5oa3
Structure name
human 40s-eif2d-re-initiation complex
Structure deposition date
2017-06-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
6
% buried
42
Peptide accession
Q5RKT7
Residue number A
141
Residue number B
144
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 141 of Ubiquitin-40S ribosomal protein S27a
Cysteine 144 of Ubiquitin-40S ribosomal protein S27a
5oa3 f 121 f 141
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 121 and 141.
Details
Redox score ?
81
PDB code
5oa3
Structure name
human 40s-eif2d-re-initiation complex
Structure deposition date
2017-06-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
44
Peptide accession
Q5RKT7
Residue number A
121
Residue number B
141
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 121 of Ubiquitin-40S ribosomal protein S27a
Cysteine 141 of Ubiquitin-40S ribosomal protein S27a
5oa3 f 126 f 141
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 126 and 141.
Details
Redox score ?
77
PDB code
5oa3
Structure name
human 40s-eif2d-re-initiation complex
Structure deposition date
2017-06-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
48
Peptide accession
Q5RKT7
Residue number A
126
Residue number B
141
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 126 of Ubiquitin-40S ribosomal protein S27a
Cysteine 141 of Ubiquitin-40S ribosomal protein S27a
6g5h f 144 f 145
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 144 and 145.
Details
Redox score ?
64
PDB code
6g5h
Structure name
cryo-em structure of a late human pre-40s ribosomal subunit - mature
Structure deposition date
2018-03-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
44
Peptide accession
Q5RKT7
Residue number A
144
Residue number B
145
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 144 of Ubiquitin-40S ribosomal protein S27a
Cysteine 145 of Ubiquitin-40S ribosomal protein S27a
5oa3 f 141 f 145
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 141 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
5oa3
Structure name
human 40s-eif2d-re-initiation complex
Structure deposition date
2017-06-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
45
Minimum pKa ?
10
% buried
60
Peptide accession
Q5RKT7
Residue number A
141
Residue number B
145
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 141 of Ubiquitin-40S ribosomal protein S27a
Cysteine 145 of Ubiquitin-40S ribosomal protein S27a
5oa3 f 121 f 145
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 121 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5oa3
Structure name
human 40s-eif2d-re-initiation complex
Structure deposition date
2017-06-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
44
Peptide accession
Q5RKT7
Residue number A
121
Residue number B
145
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 121 of Ubiquitin-40S ribosomal protein S27a
Cysteine 145 of Ubiquitin-40S ribosomal protein S27a
5oa3 f 126 f 145
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 126 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5oa3
Structure name
human 40s-eif2d-re-initiation complex
Structure deposition date
2017-06-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
41
Minimum pKa ?
11
% buried
47
Peptide accession
Q5RKT7
Residue number A
126
Residue number B
145
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 126 of Ubiquitin-40S ribosomal protein S27a
Cysteine 145 of Ubiquitin-40S ribosomal protein S27a
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