ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Exosome complex component MTR3

Intramolecular
Cysteine 183 and cysteine 248
Cysteine 64 and cysteine 98 L
A redox-regulated disulphide may form within Exosome complex component MTR3 between cysteines 183 and 248. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
85
Peptide accession
Q5RKV6
Residue number A
183
Residue number B
248
Peptide name
Exosome complex component MTR3

Ligandability

Cysteine 183 of Exosome complex component MTR3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Exosome complex component MTR3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component MTR3 between cysteines 64 and 98. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6h25
Structure name
human nuclear rna exosome exo-10-mpp6 complex
Structure deposition date
2018-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
93
Peptide accession
Q5RKV6
Residue number A
64
Residue number B
98
Peptide name
Exosome complex component MTR3

Ligandability

Cysteine 64 of Exosome complex component MTR3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Exosome complex component MTR3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: