ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cation channel sperm-associated auxiliary subunit epsilon

Intermolecular
Cysteine 384 of Cation channel sperm-associated auxiliary subunit delta and cysteine 680
Intramolecular
Cysteine 838 and cysteine 869
Cysteine 439 and cysteine 442
Cysteine 617 and cysteine 724
Cysteine 753 and cysteine 786
Cysteine 87 and cysteine 101
Cysteine 737 and cysteine 919
Cysteine 275 and cysteine 365
Cysteine 130 and cysteine 235
A redox-regulated disulphide may form between cysteine 384 of Cation channel sperm-associated auxiliary subunit delta and cysteine 680 of Cation channel sperm-associated auxiliary subunit epsilon. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
nan
Peptide A name
Cation channel sperm-associated auxiliary subunit delta
Peptide B name
Cation channel sperm-associated auxiliary subunit epsilon
Peptide A accession
E9Q9F6
Peptide B accession
P0DP43
Peptide A residue number
384
Peptide B residue number
680

Ligandability

Cysteine 384 of Cation channel sperm-associated auxiliary subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 680 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit epsilon between cysteines 838 and 869.

Details

Redox score ?
89
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DP43
Residue number A
838
Residue number B
869
Peptide name
Cation channel sperm-associated auxiliary subunit epsilon

Ligandability

Cysteine 838 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 869 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit epsilon between cysteines 439 and 442.

Details

Redox score ?
86
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DP43
Residue number A
439
Residue number B
442
Peptide name
Cation channel sperm-associated auxiliary subunit epsilon

Ligandability

Cysteine 439 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 442 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit epsilon between cysteines 617 and 724.

Details

Redox score ?
86
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DP43
Residue number A
617
Residue number B
724
Peptide name
Cation channel sperm-associated auxiliary subunit epsilon

Ligandability

Cysteine 617 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 724 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit epsilon between cysteines 753 and 786.

Details

Redox score ?
85
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
25
Peptide accession
P0DP43
Residue number A
753
Residue number B
786
Peptide name
Cation channel sperm-associated auxiliary subunit epsilon

Ligandability

Cysteine 753 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 786 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit epsilon between cysteines 87 and 101.

Details

Redox score ?
83
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
48
Peptide accession
P0DP43
Residue number A
87
Residue number B
101
Peptide name
Cation channel sperm-associated auxiliary subunit epsilon

Ligandability

Cysteine 87 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit epsilon between cysteines 737 and 919.

Details

Redox score ?
81
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DP43
Residue number A
737
Residue number B
919
Peptide name
Cation channel sperm-associated auxiliary subunit epsilon

Ligandability

Cysteine 737 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 919 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit epsilon between cysteines 275 and 365.

Details

Redox score ?
81
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DP43
Residue number A
275
Residue number B
365
Peptide name
Cation channel sperm-associated auxiliary subunit epsilon

Ligandability

Cysteine 275 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit epsilon between cysteines 130 and 235.

Details

Redox score ?
80
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DP43
Residue number A
130
Residue number B
235
Peptide name
Cation channel sperm-associated auxiliary subunit epsilon

Ligandability

Cysteine 130 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 235 of Cation channel sperm-associated auxiliary subunit epsilon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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