ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Putative methyltransferase C9orf114

Intermolecular
Cysteine 343 and cysteine 108
A redox-regulated disulphide may form between two units of Putative methyltransferase C9orf114 at cysteines 343 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4rg1
Structure name
methyltransferase domain of c9orf114
Structure deposition date
2014-09-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide A name
Putative methyltransferase C9orf114
Peptide B name
Putative methyltransferase C9orf114
Peptide A accession
Q5T280
Peptide B accession
Q5T280
Peptide A residue number
343
Peptide B residue number
108

Ligandability

Cysteine 343 of Putative methyltransferase C9orf114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Putative methyltransferase C9orf114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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