ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Adhesion G-protein coupled receptor F1

Intermolecular
Cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1 and cysteine 626
Intramolecular
Cysteine 657 and cysteine 733
Cysteine 704 and cysteine 709
Cysteine 603 and cysteine 836
A redox-regulated disulphide may form between cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1 and cysteine 626 of Adhesion G-protein coupled receptor F1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7wu5
Structure name
cryo-em structure of the adhesion gpcr adgrf1(h565a/t567a) in complex with minigi
Structure deposition date
2022-02-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
100
Peptide A name
Guanine nucleotide-binding protein G(i) subunit alpha-1
Peptide B name
Adhesion G-protein coupled receptor F1
Peptide A accession
P63096
Peptide B accession
Q5T601
Peptide A residue number
351
Peptide B residue number
626

Ligandability

Cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 626 of Adhesion G-protein coupled receptor F1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adhesion G-protein coupled receptor F1 between cysteines 657 and 733.

Details

Redox score ?
86
PDB code
7wxu
Structure name
gpr110/gq complex
Structure deposition date
2022-02-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T601
Residue number A
657
Residue number B
733
Peptide name
Adhesion G-protein coupled receptor F1

Ligandability

Cysteine 657 of Adhesion G-protein coupled receptor F1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 733 of Adhesion G-protein coupled receptor F1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adhesion G-protein coupled receptor F1 between cysteines 704 and 709. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7wxw
Structure name
gpr110/gs complex
Structure deposition date
2022-02-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
3
Peptide accession
Q5T601
Residue number A
704
Residue number B
709
Peptide name
Adhesion G-protein coupled receptor F1

Ligandability

Cysteine 704 of Adhesion G-protein coupled receptor F1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 709 of Adhesion G-protein coupled receptor F1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adhesion G-protein coupled receptor F1 between cysteines 603 and 836. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7wz7
Structure name
gpr110/g12 complex
Structure deposition date
2022-02-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
52
Peptide accession
Q5T601
Residue number A
603
Residue number B
836
Peptide name
Adhesion G-protein coupled receptor F1

Ligandability

Cysteine 603 of Adhesion G-protein coupled receptor F1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 836 of Adhesion G-protein coupled receptor F1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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