Probable G-protein coupled receptor 158
Intramolecular
Cysteine 395 and cysteine 402
Cysteine 330 and cysteine 352
Cysteine 99 and cysteine 272
Cysteine 318 and cysteine 337
Cysteine 354 and cysteine 392
Cysteine 481 and cysteine 573
Cysteine 318 and cysteine 354
Cysteine 399 and cysteine 408
Cysteine 395 and cysteine 408
Cysteine 395 and cysteine 399
More...Cysteine 402 and cysteine 408
Cysteine 330 and cysteine 392
Cysteine 330 and cysteine 337
Cysteine 352 and cysteine 392
Cysteine 352 and cysteine 354
Cysteine 392 and cysteine 402
Cysteine 330 and cysteine 354
Cysteine 318 and cysteine 352
Cysteine 354 and cysteine 395
Cysteine 354 and cysteine 402
Cysteine 318 and cysteine 330
Cysteine 337 and cysteine 392
Cysteine 399 and cysteine 402
Cysteine 337 and cysteine 352
7ewl B 395 B 402
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 395 and 402.
Details
Redox score ?
91
PDB code
7ewl
Structure name
cryo-em structure of apo gpr158
Structure deposition date
2021-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
395
Residue number B
402
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 395 of Probable G-protein coupled receptor 158
Cysteine 402 of Probable G-protein coupled receptor 158
7ewp A 330 A 352
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 330 and 352.
Details
Redox score ?
89
PDB code
7ewp
Structure name
cryo-em structure of human gpr158 in complex with rgs7-gbeta5 in a 2:1:1 ratio
Structure deposition date
2021-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
330
Residue number B
352
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 330 of Probable G-protein coupled receptor 158
Cysteine 352 of Probable G-protein coupled receptor 158
7she A 99 A 272
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 99 and 272.
Details
Redox score ?
86
PDB code
7she
Structure name
cryo-em structure of human gpr158
Structure deposition date
2021-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
99
Residue number B
272
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 99 of Probable G-protein coupled receptor 158
Cysteine 272 of Probable G-protein coupled receptor 158
7ewl B 318 B 337
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 318 and 337.
Details
Redox score ?
86
PDB code
7ewl
Structure name
cryo-em structure of apo gpr158
Structure deposition date
2021-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
318
Residue number B
337
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 318 of Probable G-protein coupled receptor 158
Cysteine 337 of Probable G-protein coupled receptor 158
7ewp B 354 B 392
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 354 and 392.
Details
Redox score ?
85
PDB code
7ewp
Structure name
cryo-em structure of human gpr158 in complex with rgs7-gbeta5 in a 2:1:1 ratio
Structure deposition date
2021-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
354
Residue number B
392
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 354 of Probable G-protein coupled receptor 158
Cysteine 392 of Probable G-protein coupled receptor 158
7shf B 481 B 573
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 481 and 573.
Details
Redox score ?
83
PDB code
7shf
Structure name
cryo-em structure of gpr158 coupled to the rgs7-gbeta5 complex
Structure deposition date
2021-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
481
Residue number B
573
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 481 of Probable G-protein coupled receptor 158
Cysteine 573 of Probable G-protein coupled receptor 158
7she B 318 B 354
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 318 and 354.
Details
Redox score ?
81
PDB code
7she
Structure name
cryo-em structure of human gpr158
Structure deposition date
2021-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
318
Residue number B
354
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 318 of Probable G-protein coupled receptor 158
Cysteine 354 of Probable G-protein coupled receptor 158
7she B 399 B 408
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 399 and 408.
Details
Redox score ?
75
PDB code
7she
Structure name
cryo-em structure of human gpr158
Structure deposition date
2021-10-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
1
Peptide accession
Q5T848
Residue number A
399
Residue number B
408
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 399 of Probable G-protein coupled receptor 158
Cysteine 408 of Probable G-protein coupled receptor 158
7ewp A 395 A 408
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 395 and 408.
Details
Redox score ?
67
PDB code
7ewp
Structure name
cryo-em structure of human gpr158 in complex with rgs7-gbeta5 in a 2:1:1 ratio
Structure deposition date
2021-05-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
395
Residue number B
408
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 395 of Probable G-protein coupled receptor 158
Cysteine 408 of Probable G-protein coupled receptor 158
7ewl B 395 B 399
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 395 and 399.
Details
Redox score ?
66
PDB code
7ewl
Structure name
cryo-em structure of apo gpr158
Structure deposition date
2021-05-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
395
Residue number B
399
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 395 of Probable G-protein coupled receptor 158
Cysteine 399 of Probable G-protein coupled receptor 158
7ewl A 402 A 408
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 402 and 408.
Details
Redox score ?
63
PDB code
7ewl
Structure name
cryo-em structure of apo gpr158
Structure deposition date
2021-05-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
402
Residue number B
408
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 402 of Probable G-protein coupled receptor 158
Cysteine 408 of Probable G-protein coupled receptor 158
7ewl B 330 B 392
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 330 and 392.
Details
Redox score ?
62
PDB code
7ewl
Structure name
cryo-em structure of apo gpr158
Structure deposition date
2021-05-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
330
Residue number B
392
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 330 of Probable G-protein coupled receptor 158
Cysteine 392 of Probable G-protein coupled receptor 158
7ewl B 330 B 337
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 330 and 337.
Details
Redox score ?
60
PDB code
7ewl
Structure name
cryo-em structure of apo gpr158
Structure deposition date
2021-05-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
330
Residue number B
337
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 330 of Probable G-protein coupled receptor 158
Cysteine 337 of Probable G-protein coupled receptor 158
7ewl B 352 B 392
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 352 and 392. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7ewl
Structure name
cryo-em structure of apo gpr158
Structure deposition date
2021-05-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
352
Residue number B
392
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 352 of Probable G-protein coupled receptor 158
Cysteine 392 of Probable G-protein coupled receptor 158
7ewl B 352 B 354
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 352 and 354. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7ewl
Structure name
cryo-em structure of apo gpr158
Structure deposition date
2021-05-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
352
Residue number B
354
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 352 of Probable G-protein coupled receptor 158
Cysteine 354 of Probable G-protein coupled receptor 158
7ewr A 392 A 402
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 392 and 402. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7ewr
Structure name
cryo-em structure of human gpr158 in complex with rgs7-gbeta5 in a 2:2:2 ratio
Structure deposition date
2021-05-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
392
Residue number B
402
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 392 of Probable G-protein coupled receptor 158
Cysteine 402 of Probable G-protein coupled receptor 158
7ewp B 330 B 354
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 330 and 354. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7ewp
Structure name
cryo-em structure of human gpr158 in complex with rgs7-gbeta5 in a 2:1:1 ratio
Structure deposition date
2021-05-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
330
Residue number B
354
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 330 of Probable G-protein coupled receptor 158
Cysteine 354 of Probable G-protein coupled receptor 158
7she B 318 B 352
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 318 and 352. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7she
Structure name
cryo-em structure of human gpr158
Structure deposition date
2021-10-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
318
Residue number B
352
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 318 of Probable G-protein coupled receptor 158
Cysteine 352 of Probable G-protein coupled receptor 158
7ewl A 354 A 395
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 354 and 395. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7ewl
Structure name
cryo-em structure of apo gpr158
Structure deposition date
2021-05-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
354
Residue number B
395
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 354 of Probable G-protein coupled receptor 158
Cysteine 395 of Probable G-protein coupled receptor 158
7ewp A 354 A 402
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 354 and 402. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7ewp
Structure name
cryo-em structure of human gpr158 in complex with rgs7-gbeta5 in a 2:1:1 ratio
Structure deposition date
2021-05-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
354
Residue number B
402
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 354 of Probable G-protein coupled receptor 158
Cysteine 402 of Probable G-protein coupled receptor 158
7she A 318 A 330
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 318 and 330. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7she
Structure name
cryo-em structure of human gpr158
Structure deposition date
2021-10-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
318
Residue number B
330
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 318 of Probable G-protein coupled receptor 158
Cysteine 330 of Probable G-protein coupled receptor 158
7ewr B 337 B 392
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 337 and 392. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ewr
Structure name
cryo-em structure of human gpr158 in complex with rgs7-gbeta5 in a 2:2:2 ratio
Structure deposition date
2021-05-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
337
Residue number B
392
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 337 of Probable G-protein coupled receptor 158
Cysteine 392 of Probable G-protein coupled receptor 158
7she A 399 A 402
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 399 and 402. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7she
Structure name
cryo-em structure of human gpr158
Structure deposition date
2021-10-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
399
Residue number B
402
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 399 of Probable G-protein coupled receptor 158
Cysteine 402 of Probable G-protein coupled receptor 158
7she B 337 B 352
A redox-regulated disulphide may form within Probable G-protein coupled receptor 158 between cysteines 337 and 352. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7she
Structure name
cryo-em structure of human gpr158
Structure deposition date
2021-10-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T848
Residue number A
337
Residue number B
352
Peptide name
Probable G-protein coupled receptor 158
Ligandability
Cysteine 337 of Probable G-protein coupled receptor 158
Cysteine 352 of Probable G-protein coupled receptor 158
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