ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein wntless homolog

Intramolecular
Cysteine 162 and cysteine 179
Cysteine 50 and cysteine 71
Cysteine 348 and cysteine 388
Cysteine 388 and cysteine 390
Cysteine 319 and cysteine 397
A redox-regulated disulphide may form within Protein wntless homolog between cysteines 162 and 179.

Details

Redox score ?
90
PDB code
7kc4
Structure name
human wls in complex with wnt8a
Structure deposition date
2020-10-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T9L3
Residue number A
162
Residue number B
179
Peptide name
Protein wntless homolog

Ligandability

Cysteine 162 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein wntless homolog between cysteines 50 and 71.

Details

Redox score ?
83
PDB code
7kc4
Structure name
human wls in complex with wnt8a
Structure deposition date
2020-10-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5T9L3
Residue number A
50
Residue number B
71
Peptide name
Protein wntless homolog

Ligandability

Cysteine 50 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein wntless homolog between cysteines 348 and 388.

Details

Redox score ?
62
PDB code
7drt
Structure name
human wntless in complex with wnt3a
Structure deposition date
2020-12-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
5
Peptide accession
Q5T9L3
Residue number A
348
Residue number B
388
Peptide name
Protein wntless homolog

Ligandability

Cysteine 348 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 388 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein wntless homolog between cysteines 388 and 390. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7drt
Structure name
human wntless in complex with wnt3a
Structure deposition date
2020-12-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
5
Peptide accession
Q5T9L3
Residue number A
388
Residue number B
390
Peptide name
Protein wntless homolog

Ligandability

Cysteine 388 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 390 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein wntless homolog between cysteines 319 and 397. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7kc4
Structure name
human wls in complex with wnt8a
Structure deposition date
2020-10-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
49
Peptide accession
Q5T9L3
Residue number A
319
Residue number B
397
Peptide name
Protein wntless homolog

Ligandability

Cysteine 319 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Protein wntless homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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