Integrator complex subunit 11
Intermolecular
Cysteine 542 and cysteine 542
Cysteine 637 of Integrator complex subunit 9 and cysteine 513
Intramolecular
Cysteine 74 and cysteine 100
Cysteine 100 and cysteine 129
Cysteine 33 and cysteine 100
Cysteine 33 and cysteine 129
Cysteine 19 and cysteine 33
Cysteine 33 and cysteine 74
Cysteine 74 and cysteine 129
5v8w B 542 D 542
A redox-regulated disulphide may form between two units of Integrator complex subunit 11 at cysteines 542 and 542.
Details
Redox score ?
82
PDB code
5v8w
Structure name
crystal structure of human integrator ints9-ints11 ctd complex
Structure deposition date
2017-03-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide A name
Integrator complex subunit 11
Peptide B name
Integrator complex subunit 11
Peptide A accession
Q5TA45
Peptide B accession
Q5TA45
Peptide A residue number
542
Peptide B residue number
542
Ligandability
5v8w A 637 B 513
A redox-regulated disulphide may form between cysteine 637 of Integrator complex subunit 9 and cysteine 513 of Integrator complex subunit 11. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
5v8w
Structure name
crystal structure of human integrator ints9-ints11 ctd complex
Structure deposition date
2017-03-22
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
82
Peptide A name
Integrator complex subunit 9
Peptide B name
Integrator complex subunit 11
Peptide A accession
Q9NV88
Peptide B accession
Q5TA45
Peptide A residue number
637
Peptide B residue number
513
Ligandability
Cysteine 637 of Integrator complex subunit 9
Cysteine 513 of Integrator complex subunit 11
7bfq B 74 B 100
A redox-regulated disulphide may form within Integrator complex subunit 11 between cysteines 74 and 100.
Details
Redox score ?
72
PDB code
7bfq
Structure name
structure of the integrator cleavage module with extended ints4 and rigid body docked ints9/11 ctd
Structure deposition date
2021-01-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
Q5TA45
Residue number A
74
Residue number B
100
Peptide name
Integrator complex subunit 11
Ligandability
Cysteine 74 of Integrator complex subunit 11
Cysteine 100 of Integrator complex subunit 11
7bfq B 100 B 129
A redox-regulated disulphide may form within Integrator complex subunit 11 between cysteines 100 and 129. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
7bfq
Structure name
structure of the integrator cleavage module with extended ints4 and rigid body docked ints9/11 ctd
Structure deposition date
2021-01-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
94
Peptide accession
Q5TA45
Residue number A
100
Residue number B
129
Peptide name
Integrator complex subunit 11
Ligandability
Cysteine 100 of Integrator complex subunit 11
Cysteine 129 of Integrator complex subunit 11
7bfp B 33 B 100
A redox-regulated disulphide may form within Integrator complex subunit 11 between cysteines 33 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7bfp
Structure name
structure of the integrator cleavage module with ints4/9/11
Structure deposition date
2021-01-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
100
Peptide accession
Q5TA45
Residue number A
33
Residue number B
100
Peptide name
Integrator complex subunit 11
Ligandability
Cysteine 33 of Integrator complex subunit 11
Cysteine 100 of Integrator complex subunit 11
7bfp B 33 B 129
A redox-regulated disulphide may form within Integrator complex subunit 11 between cysteines 33 and 129. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7bfp
Structure name
structure of the integrator cleavage module with ints4/9/11
Structure deposition date
2021-01-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
94
Peptide accession
Q5TA45
Residue number A
33
Residue number B
129
Peptide name
Integrator complex subunit 11
Ligandability
Cysteine 33 of Integrator complex subunit 11
Cysteine 129 of Integrator complex subunit 11
7bfq B 19 B 33
A redox-regulated disulphide may form within Integrator complex subunit 11 between cysteines 19 and 33. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7bfq
Structure name
structure of the integrator cleavage module with extended ints4 and rigid body docked ints9/11 ctd
Structure deposition date
2021-01-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
Q5TA45
Residue number A
19
Residue number B
33
Peptide name
Integrator complex subunit 11
Ligandability
Cysteine 19 of Integrator complex subunit 11
Cysteine 33 of Integrator complex subunit 11
7bfp B 33 B 74
A redox-regulated disulphide may form within Integrator complex subunit 11 between cysteines 33 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7bfp
Structure name
structure of the integrator cleavage module with ints4/9/11
Structure deposition date
2021-01-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
15
% buried
100
Peptide accession
Q5TA45
Residue number A
33
Residue number B
74
Peptide name
Integrator complex subunit 11
Ligandability
Cysteine 33 of Integrator complex subunit 11
Cysteine 74 of Integrator complex subunit 11
7bfq B 74 B 129
A redox-regulated disulphide may form within Integrator complex subunit 11 between cysteines 74 and 129. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
7bfq
Structure name
structure of the integrator cleavage module with extended ints4 and rigid body docked ints9/11 ctd
Structure deposition date
2021-01-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
94
Peptide accession
Q5TA45
Residue number A
74
Residue number B
129
Peptide name
Integrator complex subunit 11
Ligandability
Cysteine 74 of Integrator complex subunit 11
Cysteine 129 of Integrator complex subunit 11
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