ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ceramide-1-phosphate transfer protein

Intermolecular
Cysteine 163 and cysteine 163
Intramolecular
Cysteine 138 and cysteine 163
A redox-regulated disulphide may form between two units of Ceramide-1-phosphate transfer protein at cysteines 163 and 163.

Details

Redox score ?
71
PDB code
4k85
Structure name
crystal structure of human ceramide-1-phosphate transfer protein (cptp) in complex with 12:0 ceramide-1-phosphate (12:0-c1p)
Structure deposition date
2013-04-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
7
% buried
82
Peptide A name
Ceramide-1-phosphate transfer protein
Peptide B name
Ceramide-1-phosphate transfer protein
Peptide A accession
Q5TA50
Peptide B accession
Q5TA50
Peptide A residue number
163
Peptide B residue number
163

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceramide-1-phosphate transfer protein between cysteines 138 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
4k85
Structure name
crystal structure of human ceramide-1-phosphate transfer protein (cptp) in complex with 12:0 ceramide-1-phosphate (12:0-c1p)
Structure deposition date
2013-04-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
13
% buried
91
Peptide accession
Q5TA50
Residue number A
138
Residue number B
163
Peptide name
Ceramide-1-phosphate transfer protein

Ligandability

Cysteine 138 of Ceramide-1-phosphate transfer protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Ceramide-1-phosphate transfer protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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