ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Terminal uridylyltransferase 4

Intramolecular
Cysteine 306 and cysteine 309
Cysteine 458 and cysteine 467
Cysteine 540 and cysteine 652
A redox-regulated disulphide may form within Terminal uridylyltransferase 4 between cysteines 306 and 309.

Details

Redox score ?
79
PDB code
6iw6
Structure name
crystal structure of the lin28-interacting module of human tut4
Structure deposition date
2018-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
22
Peptide accession
Q5TAX3
Residue number A
306
Residue number B
309
Peptide name
Terminal uridylyltransferase 4

Ligandability

Cysteine 306 of Terminal uridylyltransferase 4

Cysteine 309 of Terminal uridylyltransferase 4

A redox-regulated disulphide may form within Terminal uridylyltransferase 4 between cysteines 458 and 467.

Details

Redox score ?
69
PDB code
6iw6
Structure name
crystal structure of the lin28-interacting module of human tut4
Structure deposition date
2018-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
84
Peptide accession
Q5TAX3
Residue number A
458
Residue number B
467
Peptide name
Terminal uridylyltransferase 4

Ligandability

Cysteine 458 of Terminal uridylyltransferase 4

Cysteine 467 of Terminal uridylyltransferase 4

A redox-regulated disulphide may form within Terminal uridylyltransferase 4 between cysteines 540 and 652. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6iw6
Structure name
crystal structure of the lin28-interacting module of human tut4
Structure deposition date
2018-12-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
92
Peptide accession
Q5TAX3
Residue number A
540
Residue number B
652
Peptide name
Terminal uridylyltransferase 4

Ligandability

Cysteine 540 of Terminal uridylyltransferase 4

Cysteine 652 of Terminal uridylyltransferase 4

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