a tool for identifying drug-targetable redox-active disulphides

Mitogen-activated protein kinase kinase kinase 21

Intramolecular

Cysteine 190 and cysteine 197

A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 21 between cysteines 190 and 197.

Details

Redox score ?

70

PDB code

Structure name

structure of mlk4 kinase domain with atpgammas

Structure deposition date

2014-08-29

Thiol separation (Å)

4

Half-sphere exposure sum ?

69

Minimum pK_a ?

9

% buried

28

Peptide accession

Residue number A

190

Residue number B

197

Peptide name

Mitogen-activated protein kinase kinase kinase 21

Ligandability

Cysteine 190 of Mitogen-activated protein kinase kinase kinase 21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Mitogen-activated protein kinase kinase kinase 21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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