ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Four and a half LIM domains protein 5

Intramolecular
Cysteine 252 and cysteine 255
Cysteine 252 and cysteine 273
Cysteine 252 and cysteine 276
Cysteine 222 and cysteine 225
Cysteine 222 and cysteine 249
Cysteine 273 and cysteine 276
Cysteine 255 and cysteine 273
Cysteine 225 and cysteine 249
Cysteine 255 and cysteine 276
A redox-regulated disulphide may form within Four and a half LIM domains protein 5 between cysteines 252 and 255 (38 and 41 respectively in this structure).

Details

Redox score ?
83
PDB code
1x68
Structure name
solution structures of the c-terminal lim domain of human fhl5 protein
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
6
% buried
0
Peptide accession
Q5TD97
Residue number A
252
Residue number B
255
Peptide name
Four and a half LIM domains protein 5

Ligandability

Cysteine 252 of Four and a half LIM domains protein 5

Cysteine 255 of Four and a half LIM domains protein 5

A redox-regulated disulphide may form within Four and a half LIM domains protein 5 between cysteines 252 and 273 (38 and 59 respectively in this structure).

Details

Redox score ?
82
PDB code
1x68
Structure name
solution structures of the c-terminal lim domain of human fhl5 protein
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
0
Peptide accession
Q5TD97
Residue number A
252
Residue number B
273
Peptide name
Four and a half LIM domains protein 5

Ligandability

Cysteine 252 of Four and a half LIM domains protein 5

Cysteine 273 of Four and a half LIM domains protein 5

A redox-regulated disulphide may form within Four and a half LIM domains protein 5 between cysteines 252 and 276 (38 and 62 respectively in this structure).

Details

Redox score ?
81
PDB code
1x68
Structure name
solution structures of the c-terminal lim domain of human fhl5 protein
Structure deposition date
2005-05-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
0
Peptide accession
Q5TD97
Residue number A
252
Residue number B
276
Peptide name
Four and a half LIM domains protein 5

Ligandability

Cysteine 252 of Four and a half LIM domains protein 5

Cysteine 276 of Four and a half LIM domains protein 5

A redox-regulated disulphide may form within Four and a half LIM domains protein 5 between cysteines 222 and 225 (8 and 11 respectively in this structure).

Details

Redox score ?
79
PDB code
1x68
Structure name
solution structures of the c-terminal lim domain of human fhl5 protein
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
7
% buried
0
Peptide accession
Q5TD97
Residue number A
222
Residue number B
225
Peptide name
Four and a half LIM domains protein 5

Ligandability

Cysteine 222 of Four and a half LIM domains protein 5

Cysteine 225 of Four and a half LIM domains protein 5

A redox-regulated disulphide may form within Four and a half LIM domains protein 5 between cysteines 222 and 249 (8 and 35 respectively in this structure).

Details

Redox score ?
78
PDB code
1x68
Structure name
solution structures of the c-terminal lim domain of human fhl5 protein
Structure deposition date
2005-05-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
0
Peptide accession
Q5TD97
Residue number A
222
Residue number B
249
Peptide name
Four and a half LIM domains protein 5

Ligandability

Cysteine 222 of Four and a half LIM domains protein 5

Cysteine 249 of Four and a half LIM domains protein 5

A redox-regulated disulphide may form within Four and a half LIM domains protein 5 between cysteines 273 and 276 (59 and 62 respectively in this structure).

Details

Redox score ?
78
PDB code
1x68
Structure name
solution structures of the c-terminal lim domain of human fhl5 protein
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
0
Peptide accession
Q5TD97
Residue number A
273
Residue number B
276
Peptide name
Four and a half LIM domains protein 5

Ligandability

Cysteine 273 of Four and a half LIM domains protein 5

Cysteine 276 of Four and a half LIM domains protein 5

A redox-regulated disulphide may form within Four and a half LIM domains protein 5 between cysteines 255 and 273 (41 and 59 respectively in this structure).

Details

Redox score ?
71
PDB code
1x68
Structure name
solution structures of the c-terminal lim domain of human fhl5 protein
Structure deposition date
2005-05-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
43
Minimum pKa ?
8
% buried
0
Peptide accession
Q5TD97
Residue number A
255
Residue number B
273
Peptide name
Four and a half LIM domains protein 5

Ligandability

Cysteine 255 of Four and a half LIM domains protein 5

Cysteine 273 of Four and a half LIM domains protein 5

A redox-regulated disulphide may form within Four and a half LIM domains protein 5 between cysteines 225 and 249 (11 and 35 respectively in this structure).

Details

Redox score ?
69
PDB code
1x68
Structure name
solution structures of the c-terminal lim domain of human fhl5 protein
Structure deposition date
2005-05-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
0
Peptide accession
Q5TD97
Residue number A
225
Residue number B
249
Peptide name
Four and a half LIM domains protein 5

Ligandability

Cysteine 225 of Four and a half LIM domains protein 5

Cysteine 249 of Four and a half LIM domains protein 5

A redox-regulated disulphide may form within Four and a half LIM domains protein 5 between cysteines 255 and 276 (41 and 62 respectively in this structure).

Details

Redox score ?
68
PDB code
1x68
Structure name
solution structures of the c-terminal lim domain of human fhl5 protein
Structure deposition date
2005-05-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
0
Peptide accession
Q5TD97
Residue number A
255
Residue number B
276
Peptide name
Four and a half LIM domains protein 5

Ligandability

Cysteine 255 of Four and a half LIM domains protein 5

Cysteine 276 of Four and a half LIM domains protein 5

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