a tool for identifying drug-targetable redox-active disulphides

Chromosome 1 open reading frame 57, isoform CRA_d

Intramolecular

Cysteine 101 and cysteine 110

A redox-regulated disulphide may form within Chromosome 1 open reading frame 57, isoform CRA_d between cysteines 101 and 110 (100 and 109 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

45

PDB code

Structure name

solution structure of a human cancer-related nucleoside triphosphatase

Structure deposition date

2006-08-17

Thiol separation (Å)

9

Half-sphere exposure sum ?

57

Minimum pK_a ?

9

% buried

46

Peptide accession

Residue number A

101

Residue number B

110

Peptide name

Chromosome 1 open reading frame 57, isoform CRA_d

Ligandability

Cysteine 101 of Chromosome 1 open reading frame 57, isoform CRA_d

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Chromosome 1 open reading frame 57, isoform CRA_d

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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